Results 31 to 40 of about 32,466 (225)

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

Redox Biology, 2013
Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal).
Matthew J. Randall, Page C. Spiess, Milena Hristova, Robert J. Hondal, Albert van der Vliet   +4 more
doaj   +1 more source

Modification and inactivation of Cu,Zn-superoxide dismutase by the lipid peroxidation product, acrolein [PDF]

BMB Reports, 2013
Acrolein is the most reactive aldehydic product of lipidperoxidation and is found to be elevated in the brain whenoxidative stress is high. The effects of acrolein on the structureand function of human Cu,Zn-superoxide dismutase (SOD) wereexamined.
Jung Hoon Kang
doaj   +1 more source

P2X7 Receptor Blockade Protects Against Acrolein-Induced Bladder Damage: A Potential New Therapeutic Approach for the Treatment of Bladder Inflammatory Diseases

Frontiers in Pharmacology, 2021
Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study was to investigate the
Zhinoos Taidi, Tommy Zhou, Kate H. Moore, Kylie J. Mansfield, Lu Liu   +4 more
doaj   +1 more source

Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the rat [PDF]

, 2013
Growing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions.
Allette, Yohance M., Due, Michael R., Park, Jonghyuck, Shi, Riyi, Walls, Michael, White, Fletcher A., Zheng, Lingxing   +6 more
core   +1 more source

Synthesis of Acrolein From Glycerol Using FePO4 Catalyst in Liquid Phase Dehydration [PDF]

, 2016
Acrolein is currently produced using propylene from crude oil while its price and scarcity are increasing. A renewable material such as glycerol is an attractive alternative for acrolein production.
Abidin, A. Z. (Akhmad), Afandi, R. G. (Rani), Graha, H. P. (Hafis)   +2 more
core   +3 more sources

Repeated Low-Dose Acrolein Triggers Irreversible Lamina Propria Edema in Urinary Bladder, Transient Voiding Behavior and Widening of Eyes to Mechanical Stimuli

Cells, 2021
Acrolein is a metabolite of cyclophosphamide (CYP), an alkylating agent used for a wide range of benign and malignant diseases. CYP treatments are known to trigger hemorrhagic cystitis in patients and animals.
Sanghee Lee, Jiwoo Lee, Chandresh Khimji, Jaebeom Lee, Shelle Malkmus, Michael Albo, Tony Yaksh, George Chiang   +7 more
doaj   +1 more source

Gut Microbial Glycerol Metabolism as an Endogenous Acrolein Source

mBio, 2018
Acrolein is a highly reactive electrophile causing toxic effects, such as DNA and protein adduction, oxidative stress, endoplasmic reticulum stress, immune dysfunction, and membrane damage.
Jianbo Zhang, Shana Sturla, Christophe Lacroix, Clarissa Schwab   +3 more
doaj   +1 more source

Cross-sectional and longitudinal associations of acrolein exposure with pulmonary function alteration: Assessing the potential roles of oxidative DNA damage, inflammation, and pulmonary epithelium injury in a general adult population

Environment International, 2022
Background: Acrolein is a significant high priority hazardous air pollutant with pulmonary toxicity and the leading cause of most noncancer adverse respiratory effects among air toxics that draws great attention. Whether and how acrolein exposure impacts
Bin Wang, Linling Yu, Wei Liu, Meng Yang, Lieyang Fan, Min Zhou, Jixuan Ma, Xing Wang, Xiuque Nie, Man Cheng, Weihong Qiu, Zi Ye, Jiahao Song, Weihong Chen   +13 more
doaj   +1 more source

Synthesis and use of a stable aminal derived from TsDPEN in asymmetric organocatalysis [PDF]

, 2010
A stable aminal formed stereoselectively from (R,R)-N-tosyl-1,2-diphenyl-1,2-ethylenediamine (TsDPEN) is capable of asymmetric organocatalysis of Diels-Alder and alpha-amination reactions of ...
Clarkson, Guy J., Gosiewska, Silvia, Soni, Rina, Wills, Martin   +3 more
core   +1 more source

ROCK1 Mediates Retinal Glial Cell Migration Promoted by Acrolein

Frontiers in Medicine, 2021
Objective: Acrolein is a highly reactive aldehyde that covalently binds to cellular macromolecules and subsequently modulates cellular function. Our previous study demonstrated that acrolein induces glial cell migration, a pathological hallmark of ...
Kanae Fukutsu, Miyuki Murata, Kasumi Kikuchi, Shiho Yoshida, Kousuke Noda, Susumu Ishida   +5 more
doaj   +1 more source