Results 51 to 60 of about 32,466 (225)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Upper tropospheric ozone production from lightning NOx-impacted convection: Smoke ingestion case study from the DC3 campaign [PDF]

, 2015
©2015. American Geophysical Union. All Rights Reserved. As part of the Deep Convective Cloud and Chemistry (DC3) experiment, the National Science Foundation/National Center for Atmospheric Research (NCAR) Gulfstream-V (GV) and NASA DC-8 research aircraft
Apel, EC, Barth, MC, Basarab, BM, Blake, DR, Blake, NJ, Brune, WH, Campos, TL, Cantrell, CA, Crawford, JH, Crounse, JD, Diskin, GS, Flocke, FM, Fried, AR, Heikes, BG, Hills, AJ, Homeyer, CR, Hornbrook, RS, Huey, GL, Mikovíny, T, O'Sullivan, DW, Peischl, J, Pollack, IB, Riemer, DD, Rutledge, SA, Ryerson, TB, Weinheimer, AJ, Wennberg, PO, Wisthaler, A   +27 more
core   +1 more source

Rapid assembly of highly-functionalised difluorinated cyclooctenones via ring-closing metathesis [PDF]

, 2002
Building block methodology from trifluoroethanol and ringclosing metathesis using a Fürstner modification of Grubbs’ conditions allows the rapid synthesis of novel difluorinated ...
Kariuki, Benson M., Owton, W. Martin, Percy, Jonathan, Pintat, Stephane, Smith, Clive A., Spencer, Neil S, Thomas, Andrew C, Watson, Martin   +7 more
core   +1 more source

Uncertainty Calibration in Molecular Machine Learning: Comparing Evidential and Ensemble Approaches

Chemistry – A European Journal, EarlyView.
Raw uncertainty estimates from deep evidential regression and deep ensembles are systematically miscalibrated. Post hoc calibration aligns predicted uncertainty with true errors, improving reliability and enabling efficient active learning and reducing computational cost while preserving predictive accuracy.
Bidhan Chandra Garain, Max Pinheiro Jr., Matheus de Oliveira Bispo, Mario Barbatti   +3 more
wiley   +1 more source

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]

, 2012
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ, Brock, R, Cluitmans, JC, Dinkla, S, Fransen, J, Fuchs, B, Joosten, I, Schiller, J, Tomelleri, C, Verdurmen, WP, Wessels, K   +10 more
core   +1 more source

Combustion of Waste Rapeseed Oil and Jet Propellant‐8 Blends in a CI Engine

Energy Science &Engineering, EarlyView.
Using waste rapeseed oil (WRO) mixed with Jet Propellant‐8 (JP‐8) as fuel for a compression ignition engine. ABSTRACT The study examines the potential of blending waste rapeseed oil (WRO) with Jet Propellant‐8 (JP‐8) as a fuel for compression ignition (CI) engines.
Grzegorz Pawlak, Krzysztof Kosiuczenko, Patryk Płochocki, Mariusz Wesołowski, Jarosław Molenda, Tomasz Skrzek, Dominik Czerwonka   +6 more
wiley   +1 more source

Serum metabolome and liver transcriptome reveal acrolein inhalation-induced sex-specific homeostatic dysfunction

Scientific Reports, 2023
Acrolein, a respiratory irritant, induces systemic neuroendocrine stress. However, peripheral metabolic effects have not been examined. Male and female WKY rats were exposed to air (0 ppm) or acrolein (3.16 ppm) for 4 h, followed by immediate serum and ...
Devin I. Alewel, Katherine M. Rentschler, Thomas W. Jackson, Mette C. Schladweiler, Anna Astriab-Fisher, Paul A. Evansky, Urmila P. Kodavanti   +6 more
doaj   +1 more source

Sensitization of GSH synthesis by curcumin curtails acrolein-induced alveolar epithelial apoptosis via Keap1 cysteine conjugation: A randomized controlled trial and experimental animal model of pneumonitis

Journal of Advanced Research, 2023
Introduction: Epidemiological studies have reported an association between exposures to ambient air pollution and respiratory diseases, including chronic obstructive pulmonary disease (COPD).
Eun Hee Jo, Ji Eun Moon, Moon Han Chang, Ye Jin Lim, Jung Hyun Park, Suk Hee Lee, Young Rae Cho, Art E Cho, Seung Pil Pack, Hyeon-Wee Kim, Liana Crowley, Brandy Le, Aykin-Burns Nukhet, Yinfeng Chen, Yihang Zhong, Jiangchao Zhao, Ying Li, Hanvit Cha, Jeong Hoon Pan, Jae Kyeom Kim, Jin Hyup Lee   +20 more
doaj   +1 more source

Catalytic dehydration of glycerol to acrolein: catalysts and processes [PDF]

, 2016
The valorization of glycerol has been widely studied notably due to the oversupply of the latter from biodiesel production. Among the different upgrading reactions, dehydration to acrolein is of high interest due to the importance of acrolein as an ...
Paul, Sébastien
core  

Combining 3D printing and liquid handling to produce user-friendly reactionware for chemical synthesis and purification [PDF]

, 2013
We use two 3D-printing platforms as solid- and liquid-handling fabricators, producing sealed reactionware for chemical synthesis with the reagents, catalysts and purification apparatus integrated into monolithic devices.
Cronin, Leroy, Dragone, Vincenza, Kitson, Philip J., Symes, Mark D.   +3 more
core   +1 more source