Results 91 to 100 of about 7,838,390 (295)

Alumni Survey Data 2014 for Out in Front

, 2014
Powerpoint of the 2014 cohort alumni survey of Out in ...
Out in Front
core  

Acting out e passaggio all’atto

, 2020
Il trait d’union tra acting out e passaggio all’atto è l’angoscia: un segnale che si produce quando il soggetto si sente minacciato. Si tratta di un’esperienza improvvisa, in cui il rapporto con il mondo s’incrina, l’Altro diviene irriconoscibile ...
Lottici, Marco
core   +1 more source

A Traumatic Analysis of the First-level Witnessing Effective Enlistment in Bennett and Komunyakaa's Poems

Critical Literary Studies
The present essay focuses on the witnessing process of the enlisting poets’ effective responsiveness to the devastations they encountered; the two poets to be studied have been directly or indirectly traumatized by wars.
SeyedehYasaman Ghodsi, Narges Montakhabi Bakhtvar , Razieh Eslamieh   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Acting out a scene

, 2018
"Acting out a scene" [1959.5902.000.000], Unknown ArtistArtist and Role: Unknown ...
Unknown Artist
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Lunar Phase and Acting-Out Behavior

, 1986
Psychiatric hospital records were used to ascertain whether acting-out behavior increases during the full moon phase. Acting-out behavior is identified as that which was dangerous to self or others to the extent that either seclusion or restraint was ...
Crispin L. Terry, Mark W. Durm, Cathy R. Hammonds   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source