Results 201 to 210 of about 11,232,401 (316)

Trends in global glucose lowering medication consumption: Insights from pharmaceutical sales data (2010-2021). [PDF]

PLOS Glob Public Health
Oo MMS, Jayawardana S, Campbell A, Aitken M, Patel KV, Nasir K, Mehra M, Mossialos E.   +7 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Hostility in the ICU Waiting Room: Extrapunitive and Intropunitive Reactions Among Family Members. [PDF]

Healthcare (Basel)
Konstanti Z, Tatsis F, Stamatis K, Veroniki F, Papathanakos G, Koulouras V, Gouva M.   +6 more
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Propensity Score-matched Analysis of the Impact of Direct-acting Oral Anticoagulants on Fecal Immunochemical Test Performance. [PDF]

J Anus Rectum Colon
Hamada Y, Shigefuku A, Suzuki H, Hattori A, Umeda Y, Ikenoyama Y, Yukimoto H, Iwashita C, Fujiwara Y, Nakamura M, Horiki N, Nakagawa H.   +11 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study. [PDF]

Lancet Glob Health
Han N, Loosli T, Anderegg N, Hauser A, Josi J, Davies MA, Johnson LF, Lessells R, Günthard HF, Egger M, Kouyos RD.   +10 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Medicaid reimbursement policies for long-acting reversible contraceptives immediately postpartum: A systematic literature review. [PDF]

Public Health Pract (Oxf)
Lozano-Ortega G, Walker SE, Crespi S, Kourmaeva E, Patel VP.   +4 more
europepmc   +1 more source

Acting out of character: regulatory roles of nuclear pore complex proteins.

Developmental Cell, 2009
N. Xylourgidis, M. Fornerod
semanticscholar   +1 more source