Results 251 to 260 of about 11,232,401 (316)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Adaptation and pilot testing of a discrete choice experiment and survey on patient preferences for long-acting antiretroviral therapies for HIV in Kenya. [PDF]

AIDS Care
Maina CN, Kaggiah AW, Barthold D, Tran J, Saldarriaga EM, Simoni JM, Hauber B, Kinuthia J, Graham SM.   +8 more
europepmc   +1 more source

[ACTINg out].

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008
openaire   +1 more source

A Colony In A Nation [PDF]

, 2018
Lowe, Dan
core  

Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria. [PDF]

Microbiology (Reading)
Salcedo-Sora JE, Kell DB.
europepmc   +1 more source

English as a Second Language: Strategies and Comparisons [PDF]

, 2011
Myroup, Bekah
core   +1 more source

Addressing the Global Challenges of COPD and Asthma: A Shared Vision From the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) and the Global Initiative for Asthma (GINA). [PDF]

Respirology
Halpin DMG, Masekela R, Vogelmeier CF, Ozoh OB, Cruz AA, Reddel HK, Yorgancıoğlu A, Agusti A, Boards of Directors of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Global Initiative for Asthma (GINA).   +8 more
europepmc   +1 more source

Centrally Acting Skeletal Muscle Relaxants Sharing Molecular Targets with Drugs for Neuropathic Pain Management. [PDF]

Brain Sci
Kirchlechner-Farkas JM, Karadi DA, Boldizsár I, Essmat N, Galambos AR, Lincmajer ZP, Abbood SK, Király K, Szökő É, Tábi T, Al-Khrasani M.   +10 more
europepmc   +1 more source