Communications Biology, 2022 Actinic keratosis (AK) is a common precancerous cutaneous neoplasm that arises on chronically sun-exposed skin. AK susceptibility has a moderate genetic component, and although a few susceptibility loci have been identified, including IRF4, TYR, and MC1R,
Yuhree Kim +5 more
semanticscholar +1 more source
The Genomic Landscape of Actinic Keratosis
Journal of Investigative Dermatology, 2021 Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression from normal skin to skin with AK to ...
J. Thomson +10 more
semanticscholar +1 more source
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]
, 2017 BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz +18 more
core +2 more sources
Clincal and Experimental Dermatology, 2021 Early and accurate diagnosis of cutaneous squamous cell carcinomas (SCCs) and actinic keratoses (AK) is fundamental to reduce their associated morbidity and to select the correct treatment.
E. Cinotti +17 more
semanticscholar +1 more source
Capecitabine-induced activation of actinic keratosis: A common but underrecognized adverse event
Current Problems in Cancer: Case Reports, 2021 We report a case of a 70-year-old woman undergoing chemotherapy with capecitabine for breast cancer who presented with a diffuse erythematous facial eruption, consistent with actinic keratosis activation.
Samantha Marley +2 more
doaj +1 more source
Genomic progression of precancerous actinic keratosis to squamous cell carcinoma.
Journal of Investigative Dermatology, 2021 The mechanism underlying the progression of actinic keratosis (AK) and cutaneous squamous cell carcinoma in situ (SCCIS) to squamous cell carcinoma (SCC) remains unclear.
Y. Kim +6 more
semanticscholar +1 more source
Retinoids for prevention and treatment of actinic keratosis [PDF]
Anais Brasileiros de Dermatologia, 2013 Actinic keratosis is a common cause of dermatological consultations and it presents a strong association with squamous cell carcinoma. Many substances are used for treatment and prevention, such as retinoids.
Mayra Ianhez +3 more
doaj +1 more source
Prevalence and associated factors of skin cancer in aged nursing home residents: A multicenter prevalence study [PDF]
, 2019 Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years.
Akdeniz, Merve +4 more
core +1 more source
Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial [PDF]
, 2020 Background: Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations.
Avilés-Izquierdo +25 more
core +1 more source
Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment [PDF]
, 2017 Background: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. Objective: To
Dirschka, T. +6 more
core +1 more source