Results 81 to 90 of about 18,601 (258)

Cardiovascular Drug Use and Risk of Actinic Keratosis: A Case-Control Study

Dermatology and Therapy, 2020
Introduction Actinic keratosis (AK) is a precancerous skin lesion. Currently, many experts treat actinic keratosis as squamous cell carcinoma in situ. It is well established that exposure of the skin to ultraviolet radiation is a major risk factor for ...
Olga Warszawik-Hendzel, Małgorzata Olszewska, Adriana Rakowska, Mariusz Sikora, Piotr Hendzel, Lidia Rudnicka   +5 more
doaj   +1 more source

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, EarlyView.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source

Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream

Journal of Translational Medicine, 2007
Background The objective of this study was to identify the molecular processes responsible for the anti-lesional activity of imiquimod in subjects with actinic keratosis using global gene expression profiling.
Raghavan Shalini, Jin Jizhong, Bulbulian Barbara J, Miller Richard L, Anders Makala, Storey Leslie, Torres Abel, Lee James, Slade Herbert B, Birmachu Woubalem   +9 more
doaj   +1 more source

Swiss clinical practice guidelines on field cancerization of the skin. [PDF]

, 2014
Actinic keratosis (AK) affects millions of people worldwide, and its prevalence continues to increase. AK lesions are caused by chronic ultraviolet radiation exposure, and the presence of two or more AK lesions along with photodamage should raise the ...
Anliker, M., Boehncke, W.H., Brand, C., Braun, R., Gaide, O., Hafner, J., Hofbauer, G., Hunger, R., Itin, P., Kaeuper, G., Lautenschlager, S., Mainetti, C., Streit, M.   +12 more
core   +2 more sources

KOH 5% solution versus diclofenac 3% for the treatment of actinic keratosis – Results from a three‐armed RCT

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this RCT, KOH 5% demonstrated superior clinical success to diclofenac 3% and placebo at the end of treatment in patients with mild‐to‐moderate actinic keratosis and comparable long‐term efficacy to diclofenac. Its fast onset of efficacy and favourable tolerability make KOH a valuable treatment option in early‐stage actinic keratosis treatment ...
U. Reinhold, N. Leitz, R. Dominicus, E. L. Szabó, T. Dirschka, G. Popp, T. C. Fischer, N. Adamini, R. Ostendorf, M. Asefi, H. Durani, T. Hölting, U. Amann, F. Kreuziger, T. Assmann, H. Brüning, L. Freitag, K. Hoffmann, R. Gedschold   +18 more
wiley   +1 more source

An Unusual Case of Perineural Infiltration and Orbital Invasion of Squamous Cell Carcinoma Associated with Actinic Keratosis

Case Reports in Ophthalmological Medicine, 2020
Actinic keratosis is considered a precancerous lesion, constituting a precursor to squamous cell carcinoma (SCC) formation. Perineural invasion has been observed in patients with cutaneous carcinoma due to local subcutaneous tissue destruction and ...
Edgard Farah, Marie Callet, Augustin Leclerc, Tryfon Rotsos, Chrysanthos Symeonidis, Pierre-Vincent Jacomet, Olivier Galatoire   +6 more
doaj   +1 more source

Safety and efficacy of vismodegib in patients aged ≥65 years with advanced basal cell carcinoma. [PDF]

, 2016
Because many patients with unresectable basal cell carcinoma (BCC) are aged ≥65 years, this study explores the efficacy and safety of vismodegib in these patients with locally advanced (la) or metastatic (m) basal cell carcinoma (BCC) in the ERIVANCE BCC
Arron, Sarah, Chang, Anne, Day, Bann-Mo, Lewis, Karl, McKenna, Edward, Migden, Michael, Sekulic, Aleksandar, Solomon, James, Yoo, Simon   +8 more
core   +2 more sources

AI‐assisted basal cell carcinoma diagnosis with LC‐OCT: A multicentric retrospective study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Real‐time AI assistance significantly improves dermatologists' performance in diagnosing basal cell carcinoma with LC‐OCT, outperforming traditional imaging methods. AI‐assisted novices reached expert‐level performance, bridging a 2‐year expertise gap, thus supporting a broader clinical adoption of non‐invasive technologies, reducing the need for ...
Sébastien Fischman, Théo Viel, Jean‐Luc Perrot, Javiera Pérez‐Anker, Mariano Suppa, Elisa Cinotti, Clément Lenoir, Carmen Orte Cano, Julia Welzel, Sandra Schuh, Elke Christina Sattler, Véronique del Marmol, Pietro Rubegni, Martina Dragotto, Vittoria Cioppa, Francesca Falcinelli, Simone Cappilli, Steven Challe, Clara Tavernier, Josep Malvehy, Linda Tognetti, LC‐OCT Reviewers Consortium, Sarah Hobelsberger, Maximilian Deussing, Sandra Schuh, Simone Cappilli, Hanna Wirsching, Gerardo Palmisano, Hervé Garat, Jean‐Luc Perrot, Simone Soglia, Vinzent Kevin Ortner, Kevin Jacobsen, Sarah Kourdjee, Marco Mozaffari, Javiera Anker, Julia Welzel, Julian Steininger, Claire Thibaud, Kristina Fünfer, Francesco Lacarrubba, Frank Friedrich Gellrich, Lucas Boussingault, Christian Dorado Cortez, Carmen Orte Cano, Clément Lenoir, Tom Wolswijk, Marina Thomas, Marina Venturini, Margot Fontaine, Marie Danset, Anna Elisa Verzì, Cristel Ruini, Martina Dragotto, Alessandro Di Stefani, Agnes Venturi, Jilliana Monnier, Romain Samaran, Gwendoline Diet, Vittoria Cioppa, Elke Sattler, Lyna Mtimet, Francesca Falcinelli, Elisa Cinotti, Mariano Suppa   +64 more
wiley   +1 more source

Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel.

PLoS ONE, 2020
Actinic keratosis is a common skin disease that may progress to invasive squamous cell carcinoma if left untreated. Ingenol mebutate has demonstrated efficacy in field treatment of actinic keratosis.
Sonia Segura, Alejandra Gadea, Lara Nonell, Evelyn Andrades, Silvia Sánchez, Ramon Pujol, Inmaculada Hernández-Muñoz, Agustí Toll   +7 more
doaj   +1 more source

A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy [PDF]

, 2018
This project was supported by the University of St. Andrews through the Science and Technology Facilities Council (STFC) Impact Accelerator Award (IAA) and by the Laser Research and Therapy Fund (registered charity SC030850). P O’M is funded by Medi-lase
Brown, C. Tom A., Eadie, Ewan, Haigh, Neil, Ibbotson, Sally, O'Mahoney, Paul, Wood, Kenny   +5 more
core   +3 more sources