Results 61 to 70 of about 6,465 (327)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Navigating the safety profile of Actinium-225 targeted alpha therapy: a comprehensive review

Clinical and translational imaging
This review aims to collect the available documents on the clinical safety of Ac-225 radiopharmaceuticals targeted alpha radionuclide therapy and summarize practical safety data recommended for clinical development of Ac-225 radiopharmaceuticals.
H. Roustaei, C. D'Alessandria, Clemens Decristoforo   +2 more
semanticscholar   +1 more source

THE HALF-PERIODS OF ACTINIUM B, ACTINIUM C″, AND URANIUM X₁

, 1939
From measurements of the β-ray intensities by ionization at different times and semilogarithmic plots of these intensities against the time, the half-periods of actinium B, actinium C″, and uranium X1 were found to be 36.1 ± 0.2 min., 4.76 ± 0.02 min ...
B. W. Sargent
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Actinium-227 als Tracer für Advektion und Mischung in der Tiefsee [PDF]

, 2002
Der Artikel stellt kurz die Dissertation gleichen Titels (Actinium-227 als Tracer für Advektion und Mischung in der Tiefsee ...
Geibert, W.
core   +1 more source

Towards DFO*12—Preliminary Results of a New Chelator for the Complexation of Actinium-225

Pharmaceutics
Background: Actinium-225 (225Ac) has gained interest in nuclear medicine for use in targeted alpha therapy (TAT) for the treatment of cancer. However, the number of suitable chelators for the stable complexation of 225Ac3+ is limited.
Irene V. J. Feiner, D. Svatunek, Martin Pressler, Tori Demuth, Xabier Guarrochena, J. Sterba, S. Dorudi, Clemens Pichler, C. Denk, Thomas L. Mindt   +9 more
semanticscholar   +1 more source

Actinium-225 Targeted Agents: Where Are We Now?

Brachytherapy, 2023
α-particle targeted radionuclide therapy has shown promise for optimal cancer management, an exciting new era for brachytherapy. Alpha-emitting nuclides can have significant advantages over gamma- and beta-emitters due to their high linear energy ...
F. Mourtada, Katsumi Tomiyoshi, Jennifer Sims-Mourtada, Yuki Mukai-Sasaki, Takayuki Yagihashi, Yuta Namiki, T. Murai, David J. Yang, Tomio Inoue   +8 more
semanticscholar   +1 more source

Actinium-225 Production via Proton Irradiation of Thorium-232 [PDF]

, 2016
High energy proton spallation reactions on natural thorium metal targets have been utilized to produce multi mCi [milliCurie] quantities of Actinium-225.
Griswold, Justin Reed
core