Results 1 to 10 of about 5,403 (175)

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis [PDF]

Advanced Science
Purpose: The combination of radiotherapy and immunotherapy (radioimmunotherapy) shows promising antitumor efficacy but raises cardiotoxicity concerns. The underlying mechanisms remain unclear.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
doaj   +3 more sources

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy [PDF]

Advanced Science
The immunosuppressive tumor microenvironment (TME) promotes resistance to radiation therapy, substantially limiting the efficacy of radioimmunotherapy. Here, we report a hyaluronic acid (HA)‐coated manganese–platinum (MnPt) bimetallic nanozyme (HD@MnO2 ...
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
doaj   +3 more sources

The Effects of Radioimmunotherapy and Antibiotics on Biofilm-Associated Implant Infections in a Preclinical Rat Model. [PDF]

J Orthop Res
ABSTRACT Indwelling medical implants are susceptible to developing biofilm‐associated infections that are notoriously difficult to eradicate. These persistent infections often cannot be resolved with antibiotics alone and typically require surgical intervention for effective management.
Nurmohamed FRHA, Allen KJH, Malo ME, Frank C, Nesbitt C, van Duyvenbode JFFH, Buijs M, van der Wildt B, Poot AJ, Lam MGEH, van Strijp JAG, van der Merwe JM, Charles Vogely H, Weinans H, van der Wal BCH, Dadachova E.   +15 more
europepmc   +2 more sources

Pathogen-Specific Actinium-225 and Lutetium-177 Labeled Antibodies for Treatment of Biofilm-Associated Implant Infections: Initial In Vivo Proof-of-Concept [PDF]

Antibiotics
Background: the primary challenge with implant infections is the formation of biofilm, which harbors dormant bacteria that reduce the effectiveness of antibiotics and amplify antibiotic resistance, exacerbating the global antimicrobial resistance crisis.
F. Ruben H. A. Nurmohamed, Kevin J. H. Allen, Mackenzie E. Malo, Connor Frank, J. Fred F. Hooning van Duvenbode, Berend van der Wildt, Alex J. Poot, Marnix G. E. H. Lam, Jos A. G. van Strijp, Peter G. J. Nikkels, H. Charles Vogely, Harrie Weinans, Ekaterina Dadachova, Bart C. H. van der Wal   +13 more
doaj   +2 more sources

Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cGAS-STING activation [PDF]

Journal of Nanobiotechnology
The immunosuppressive tumor microenvironment (ITME) and inherent radioresistance of tumor cells limit the effectiveness of radioimmunotherapy and exacerbate immune evasion.
Ziting Xu, Yang Gao, Li Zhang, Yingshan Gao, Yushu Liao, Yu Liang, Zhen Yuan, Yingjia Li, Bingxia Zhao, Ge Wen   +9 more
doaj   +2 more sources

Radioimmunotherapy combating biofilm-associated infection in vitro

Frontiers in Medicine
BackgroundAddressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to Staphylococcus aureus (S.
Bart Van Der Wal, Dadachova Ekaterina, Lam Marnix G E H   +2 more
exaly   +3 more sources

Radioimmunotherapy for solid tumors: spotlight on Glypican-1 as a radioimmunotherapy target

Therapeutic Advances in Medical Oncology, 2021
Radioimmunotherapy (i.e., the use of radiolabeled tumor targeting antibodies) is an emerging approach for the diagnosis, therapy, and monitoring of solid tumors.
Dhanusha Sabanathan, Maria E. Lund, Douglas H. Campbell, Bradley J. Walsh, Howard Gurney   +4 more
doaj   +1 more source

Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer

Bioactive Materials, 2023
The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer (TNBC) is largely limited by the complicated tumor microenvironment (TME) and its immunosuppressive state.
Wei Huang, Sujiang Shi, Haoran Lv, Zhenyu Ju, Qinghua Liu, Tianfeng Chen   +5 more
doaj   +1 more source

Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer

Bioactive Materials, 2023
Aggregation-Induced Emission luminogen (AIEgen) possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety. Bacteria as a natural carrier have
Yanhong Duo, Zide Chen, Zihuang Li, Xing Li, Yaoqiang Yao, Tianzhao Xu, Ge Gao, Guanghong Luo   +7 more
doaj   +1 more source

ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer, 2020
Background Radioimmunotherapy has a promising antitumor effect in hepatocellular carcinoma (HCC), depending on the regulatory effect of radiotherapy on tumor immune microenvironment.
Hui Wang, Yan Huang, Jian Wang, Hailong Sheng, Yazhi Xiao, Zhenru Zhu, Mengying Shen, Peitao Zhou, Zeqin Guo, Wencong Dai, Wanjun Zhang, Jingyuan Sun, Chuanhui Cao   +12 more
doaj   +1 more source