Results 11 to 20 of about 9,215 (199)

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors. [PDF]

PLoS ONE, 2009
BackgroundTo date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which
Fares Al-Ejeh, Jocelyn M Darby, Michael P Brown   +2 more
doaj   +2 more sources

RADIOIMMUNOTHERAPY IN THE TREATMENT OF MALIGNANCIES

Сибирский онкологический журнал, 2016
This review presents information about one of the promising areas of targeted therapy in modern oncology, which is called radioimmunotherapy. Particular attention is paid to the possibility of clinical application of this type of systemic treatment for ...
V. I. Chernov, O. D. Bragina, I. G. Sinilkin, A. A. Titskaya, R. V. Zelchan   +4 more
doaj   +2 more sources

Supplementary Figure from Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity

, 2022
Supplementary Figure from Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low ...
Salomon Tendler (9565413), Triparna Sen (510712), Komal Mandleywala (8157900), Kathryn M. Tully (4843677), Avelyn Mae Delos Reyes (15038582), Zachary V. Samuels (15038576), Lukas M. Carter (14941741), Nagavarakishore Pillarsetty (15038585), Alessandra Piersigilli (597036), William D. Travis (14871542), John T. Poirier (14937771), Jason S. Lewis (14941759), Joshua A. Korsen (15038579), Sai Kiran Sharma (1589740), Charles M. Rudin (11572933)   +14 more
core   +12 more sources

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm
The abscopal effect is a systemic antitumor response to localized radiotherapy (RT) that has emerged as a central focus in the era of immunotherapy. Clinical evidence demonstrates that local RT can induce regression of distant, nonirradiated metastases ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
doaj   +2 more sources

Radiation-Triggered Chemokine-Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy. [PDF]

Adv Sci (Weinh)
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Liu Y, Qian Y, Huang S, Li B, Yu Y, Cheng X, Chen C, Wang J, Yang M, Liang L, Meng X, Liu Z.   +11 more
europepmc   +2 more sources

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non-Small Cell Lung Cancer. [PDF]

Cancer Sci
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Mao Q, Yu Y, Fang Y, Zhu S, Tang C, Cai J.   +5 more
europepmc   +2 more sources

The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]

, 2004
PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core   +4 more sources

Association of HRD Score With Efficacy of Neoadjuvant Short-Course Radiotherapy Plus Sequential Chemoimmunotherapy in pMMR Locally Advanced Rectal Cancer. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Homologous recombination deficiency (HRD) has been reported to be associated with increased sensitivity to platinum‐based treatment and radiotherapy in some solid tumors. Aim This study investigated the correlation between HRD score and treatment response to neoadjuvant short‐course radiotherapy combined with sequential chemotherapy
Ran X, Xiao H, Zhou P, He J, Si M, Chen X, Su X, Chen Z, Du J, Dai X, Yang X, Shen H, He Z, Li F, Li M, Chen C.   +15 more
europepmc   +2 more sources

Immunostimulatory effects of radioimmunotherapy [PDF]

Journal for ImmunoTherapy of Cancer, 2022
Radiation therapy (RT) is known for its ability to kill cancer cells in an immunogenic manner. Recent preclinical data demonstrate that targeted alpha-particle therapy shares with RT the capacity to elicit immunostimulatory effects, standing out as a promising strategy to circumvent immune checkpoint inhibitor resistance in immunologically ‘cold ...
Constanzo, Julie, Galluzzi, Lorenzo, Pouget, Jean-Pierre   +2 more
openaire   +3 more sources

Reactive Oxygen Species as Central Coordinators of Organelle Stress and Tumor Radiosensitivity. [PDF]

Cell Biochem Funct
ABSTRACT Radiotherapy is a major modality for cancer treatment, but therapeutic responses vary substantially across tumor types and patients. Beyond direct DNA damage, radiation‐induced reactive oxygen species (ROS) are increasingly recognized as dynamic regulators of cellular stress responses.
Ju G, Wang Z, Xiao J, Wu Q, Yang Z, Miao Y, Yuan S, Qian J.   +7 more
europepmc   +2 more sources