Results 21 to 30 of about 12,534 (220)

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +2 more sources

Generation and in vivo characterization of a chimeric αvβ5-targeting antibody 14C5 and its derivatives [PDF]

, 2013
Background: Previous studies showed that radiolabeled murine monoclonal antibody (mAb) 14C5 and its Fab and F(ab')2 fragments, targeting αvβ5 integrin, have promising properties for diagnostic and therapeutic applications in cancer.
De Vos, Filip, Dumolyn, Caroline, Haustraete, Jurgen, Moerman, Lieselotte, Neyt, Sara, Schoonooghe, Steve   +5 more
core   +2 more sources

Pattern of antigen expression in metastases after radioimmunotherapy of a syngeneic rat colon carcinoma utilizing the BR96 antibody

Experimental Hematology & Oncology, 2012
Background Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after ...
Elgström Erika, Eriksson Sophie E, Ohlsson Tomas G, Tennvall Jan, Nilsson Rune   +4 more
doaj   +1 more source

Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices [PDF]

, 2013
Objective The aim of this study was to investigate how head and neck squamous cell carcinoma (HNSCC) tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device respond to radiation treatment.
Burcombe R, Cai L, Eriksson D, Eriksson D, Fernberg JO, Hattersley SM, Hattersley SM, Ianzini F, Jemal A, Kamotani Y, Kroemer G, Lee P, Ma H, Mamouni J, Mansilla S, Mauk MG, Mirzaie-Joniani H, Mulhall HJ, Nevill JT, Parkin DM, Reddy AC, Remmerbach TW, Skoda C, Ts’ao C, Weigum SE, Withrow KP, Young EW, Ziober BL   +27 more
core   +2 more sources

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors.

PLoS ONE, 2009
BackgroundTo date, inefficient delivery of therapeutic doses of radionuclides to solid tumors limits the clinical utility of radioimmunotherapy. We aim to test the therapeutic utility of Yttrium-90 ((90)Y)-radio-conjugates of a monoclonal antibody, which
Fares Al-Ejeh, Jocelyn M Darby, Michael P Brown   +2 more
doaj   +1 more source

Current concepts of 131I therapy in oncology: Indications, methods and follow up [PDF]

Archive of Oncology, 2006
Radioiodine in various forms (as sodium iodide and as the iodinated compounds MIBG, LIPIODOL, et al.) has been used as a therapeutic agent in oncology. Differentiated thyroid carcinoma (DTC) has been successfully treated by 131I therapy.
Mihailović Jasna
doaj   +1 more source

Evaluation of response to fractionated radioimmunotherapy with 90Y-epratuzumab in non-Hodgkin’s lymphoma by 18F-fluorodeoxyglucose positron emission tomography

Haematologica, 2008
Background The study aimed to evaluate FDG-PET imaging for early prediction of response to radioimmunotherapy in patients with non-Hodgkin’s lymphoma.Design and Methods Twenty-seven patients from a large ongoing, multicenter, phase I/II trial of ...
Caroline Bodet-Milin, Françoise Kraeber-Bodéré, Benoît Dupas, Franck Morschhauser, Thomas Gastinne, Steven Le Gouill, Loïc Campion, Jean-Luc Harousseau, William A. Wegener, David M. Goldenberg, Damien Huglo   +10 more
doaj   +1 more source

Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]

, 2016
With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S., Carideo, Luciano, Galli, Filippo, Lauri, Chiara, Pacilio, Massimiliano, Signore, Alberto, Valabrega, Stefano   +6 more
core   +2 more sources

Radioimmunotherapy Targeting IGF2R on Canine-Patient-Derived Osteosarcoma Tumors in Mice and Radiation Dosimetry in Canine and Pediatric Models

Pharmaceuticals, 2021
Background: Osteosarcoma (OS) has an overall patient survival rate of ~70% with no significant improvements in the last two decades, and novel effective treatments are needed.
Jaline Broqueza, Chandra B. Prabaharan, Kevin J. H. Allen, Rubin Jiao, Darrell R. Fisher, Ryan Dickinson, Valerie MacDonald-Dickinson, Maruti Uppalapati, Ekaterina Dadachova   +8 more
doaj   +1 more source

Radioimmunotherapy Improves Survival of Rats with Microscopic Liver Metastases of Colorectal Origin [PDF]

, 2009
BACKGROUND: Half of the patients with colorectal cancer develop liver metastases during the course of their disease. The aim of the present study was to assess the efficacy of radioimmunotherapy (RIT) with a radiolabeled monoclonal antibody (mAb) to ...
Gabie M. de Jong, Thijs Hendriks, Annemarie Eek, Wim J. G. Oyen, Sandra Heskamp, Robert P. Bleichrodt, Otto C. Boerman, A Jemal, DM Parkin, J Scheele, KW Millikan, S Bipat, CG Moertel, TM Behr, RD Blumenthal, MJ Koppe, F Aarts, TM Behr, MS Zedeck, MJ Koppe, M Hagenaars, M Hagenaars, GM Jong, AM Lopes Cardozo, DM Goldenberg, GA Wiseman, TM Behr, MJ Koppe, TM Behr, RK Jain, AH Brouwers, F Aarts, F Aarts, MJ Koppe   +33 more
core   +1 more source