Results 181 to 190 of about 25,176 (244)
Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie +12 more
wiley +1 more source
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen +6 more
wiley +1 more source
Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley +1 more source
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley +1 more source
The Six Pillars of Lifestyle Medicine in MASLD: An Evidence‐Based Guide
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and is projected to affect more than 40% of adults by 2050. Although pharmacologic therapies are emerging, lifestyle modification remains the foundation of management.
Jigyasa Sharma, Kathleen Viveiros
wiley +1 more source
ABSTRACT Root exudates serve as a key driver for the restoration of soil organic carbon (SOC), particularly in aeolian desertification ecosystems where aboveground litter retention is limited. While Salix cupularis is widely planted as an effective pioneer shrub for ecological rehabilitation on the Qinghai‐Tibet Plateau, how the quantity of its root ...
Ran Xue +9 more
wiley +1 more source
Iron/Manganese Oxide‐Bound Nitrogen Suppresses Microbial Mediated Nitrate Reduction in Soil
ABSTRACT Nitrogen cycling plays a pivotal role in sustaining ecosystem productivity and stability, while the chemical forms of nitrogen in soils critically influence both its efficiency and pathways. In this study, farmland soils from the Anning River Basin—an important watershed in Southwest China—were investigated to examine the regulatory effects of
Yu Cheng +3 more
wiley +1 more source
ABSTRACT Autotrophic carbon‐fixing bacteria (CFB) are central contributors to soil carbon sequestration and biogeochemical carbon cycling in agroforestry ecosystems and can act as reliable biological indicators for evaluating agroforestry ecosystem sustainability.
Jingying Hei +3 more
wiley +1 more source
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley +1 more source

