Results 31 to 40 of about 2,356 (197)

New Species of the Genus Actinoplanes, Actinoplanes ferrugineus [PDF]

International Journal of Systematic Bacteriology, 1979
An extensive phenotypic characterization of an actinoplanete capable of producing the antimetabolite L-azetidine-2-carboxylic acid is presented. On the basis of the properties of this organism, it is concluded that it belongs to a new species, for which the name Actinoplanes ferrugineus is proposed. The type strain is X-14695 (= ATCC 29868).
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Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110

Frontiers in Microbiology, 2019
Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block
Lena Schaffert, Susanne Schneiker-Bekel, Susanne Schneiker-Bekel, Saskia Dymek, Julian Droste, Marcus Persicke, Tobias Busche, David Brandt, Alfred Pühler, Jörn Kalinowski   +9 more
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Actinoplanes toevensis sp. nov. and Actinoplanes tereljensis sp. nov., isolated from Mongolian soil [PDF]

International Journal of Systematic and Evolutionary Microbiology, 2010
Two novel actinomycetes, designated MN07-A0368T and MN07-A0371T, were isolated from soil of Terelj, Töv Province, Mongolia, and subjected to phenotypic and genotypic characterization. They produced well-developed, non-fragmenting, extensively branched substrate hyphae from which oval to irregular sporangia were produced. Chemotaxonomic characteristics,
Ismet, Ara, Hideki, Yamamura, Baljinova, Tsetseg, Damdinsuren, Daram, Katsuhiko, Ando   +4 more
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Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes sp. SE50/110

Synthetic and Systems Biotechnology, 2017
The α-glucosidase inhibitor acarbose is commercially produced by Actinoplanes sp. and used as a potent drug in the treatment of type-2 diabetes. In order to improve the yield of acarbose, an efficient genetic manipulation system for Actinoplanes sp.
Qinqin Zhao, Huixin Xie, Yao Peng, Xinran Wang, Linquan Bai   +4 more
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Evaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110

Microbial Cell Factories, 2019
Background Actinoplanes sp. SE50/110 is a natural producer of acarbose. It has been extensively studied in the last decades, which has led to the comprehensive analysis of the whole genome, transcriptome and proteome.
Lena Schaffert, Camilla März, Lisa Burkhardt, Julian Droste, David Brandt, Tobias Busche, Winfried Rosen, Susanne Schneiker-Bekel, Marcus Persicke, Alfred Pühler, Jörn Kalinowski   +10 more
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A severe leakage of intermediates to shunt products in acarbose biosynthesis

Nature Communications, 2020
Biosynthetic mechanism for the type 2 diabetes treatment drug acarbose is not fully revealed. Here, the authors show that shunt pathways and inefficient amino-deoxyhexose biosynthesis lead to 1-epi-valienol and valienol accumulation, and minimizing the ...
Qinqin Zhao, Yuchang Luo, Xin Zhang, Qianjin Kang, Dan Zhang, Lili Zhang, Linquan Bai, Zixin Deng   +7 more
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DIVERSITY OF ACTINOMYCETES FROM EKA KARYA BOTANICAL GARDEN, BALI

Biotropia: The Southeast Asian Journal of Tropical Biology, 2016
A total of 229 strains of actinomycetes were isolated and identified by full sequence of 16S rRNA gene analysis. Samples consisted of 18 soil and 20 leaf-litter were collected from Eka Karya Botanical Garden, Bali Island, Indonesia.
Shanti Ratnakomala, Puspita Lisdiyanti, Nita Rosalinda Prayitno, Evi Triana, Yulin Lestari, Ratih Dwi Hastuti, Yantyati Widyastuti, Misa Otoguro, Katsuhiko Ando, Endang Sukara   +9 more
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Enhanced production of select phytocannabinoids in medical Cannabis cultivars using microbial consortia

Frontiers in Plant Science, 2023
The root microbiome of medical cannabis plants has been largely unexplored due to past legal restrictions in many countries. Microbes that live on and within the tissue of Cannabis sativa L. similar to other plants, provide advantages such as stimulating
Bulbul Ahmed, Bulbul Ahmed, František Beneš, Jana Hajšlová, Lenka Fišarová, Miroslav Vosátka, Mohamed Hijri, Mohamed Hijri   +7 more
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Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus [PDF]

Microbiology, 2004
The glycopeptide teicoplanin is used for the treatment of serious infections caused by Gram-positive pathogens. The tcp gene cluster, devoted to teicoplanin biosynthesis in the actinomycete Actinoplanes teichomyceticus, was isolated and characterized. From sequence analysis, the tcp cluster spans approximately 73 kb and includes 39 ORFs participating ...
Sosio, M., Kloosterman, H., Bianchi, A., de Vreugd, P., Dijkhuizen, L., Donadio, S.   +5 more
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Reconstruction and in silico analysis of an Actinoplanes sp. SE50/110 genome-scale metabolic model for acarbose production

Frontiers in Microbiology, 2015
Actinoplanes sp. SE50/110 produces the -glucosidase inhibitor acarbose, which is used to treat type 2 diabetes mellitus. To obtain a comprehensive understanding of its cellular metabolism, a genome-scale metabolic model of strain SE50/110, iYLW1028, was
Yali eWang, Yali eWang, Yali eWang, Nan eXu, Nan eXu, Chao eYe, Chao eYe, Liming eLiu, Liming eLiu, Zhongping eShi, Zhongping eShi, Jing eWu, Jing eWu   +12 more
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