Results 1 to 10 of about 16,949 (211)

The 4-α-Glucanotransferase AcbQ Is Involved in Acarbose Modification in Actinoplanes sp. SE50/110

Microorganisms, 2023
The pseudo-tetrasaccharide acarbose, produced by Actinoplanes sp. SE50/110, is a α-glucosidase inhibitor used for treatment of type 2 diabetes patients.
Sophia Nölting, Camilla März, Lucas Jacob, Marcus Persicke, Susanne Schneiker-Bekel, Jörn Kalinowski   +5 more
doaj   +2 more sources

The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals

Translational Medicine of Aging, 2023
Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes).
A. Isman, A. Nyquist, M. Moel, X. Zhang, S. Zalzala   +4 more
doaj   +2 more sources

Enhanced acarbose production by Streptomyces M37 using a two-stage fermentation strategy. [PDF]

PLoS ONE, 2017
In this work, we investigated the effect of pH on Streptomyces M37 growth and its acarbose biosynthesis ability. We observed that low pH was beneficial for cell growth, whereas high pH favored acarbose synthesis. Moreover, addition of glucose and maltose
Fei Ren, Long Chen, Shuangli Xiong, Qunyi Tong   +3 more
doaj   +2 more sources

The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome

mSphere, 2019
Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the
Nielson T. Baxter, Nicholas A. Lesniak, Hamide Sinani, Patrick D. Schloss, Nicole M. Koropatkin   +4 more
doaj   +2 more sources

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Synthetic and Systems Biotechnology
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found
Xin Zhang, Qungang Huang, Ziyue Guo, Feifei Cai, Qianjin Kang, Linquan Bai   +5 more
doaj   +2 more sources

Continuous Glucose Monitoring Systems and the Efficacy of Acarbose Treatment in Cystic Fibrosis-related Dysglycemia [PDF]

JCRPE
Early detection of glycemic dysregulation and optimization of glycemic control in cystic fibrosis (CF) related diabetes (CFRD) is associated with improved pulmonary function and decreased mortality.
Emrullah Arslan, Deniz Özalp Kızılay, Yasemin Atik Altınok, Bahar Girgin Dündar, Arzu Jalilova, Günay Demir, Samim Özen, Şükran Darcan, Ruhsar Damla Gökşen   +8 more
doaj   +2 more sources

Metabolic syndrome treatment: focusing on acarbose

Кардиоваскулярная терапия и профилактика, 2008
Aim. To compare the effectiveness of alpha-glucosidase inhibitor acarbose (150 or 300 mg/d) and non-pharmaceutical lifestyle modification in controlling arterial hypertension (AH), carbohydrate and lipid metabolism, and body weight (BW) among patients ...
I. E. Chazova, B. B. Mychka
doaj   +2 more sources

Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Frontiers in Pharmacology, 2020
Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that acarbose influences the gut microbiota to affect the course of arthritis and tested this hypothesis in a collagen-induced arthritis (CIA) murine model. Acarbose in
Lingshu Zhang, Lingshu Zhang, Lingshu Zhang, Pingfang Song, Xiaowei Zhang, Christina Metea, Matthew Schleisman, Lisa Karstens, Eric Leung, Jun Zhang, Qiang Xu, Qiang Xu, Yi Liu, Mark Asquith, Cong-Qiu Chu, Cong-Qiu Chu   +15 more
doaj   +1 more source

MARCH2: comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients. [PDF]

PLoS ONE, 2014
The data of MARCH (Metformin and AcaRbose in Chinese as the initial Hypoglycaemic treatment) trial demonstrated that acarbose and metformin have similar efficacy as initial therapy for hemoglobin A1c (HbA1c) reduction in Chinese patients with newly ...
Guang Wang, Jia Liu, Ning Yang, Xia Gao, Hui Fan, Yuan Xu, Wenying Yang   +6 more
doaj   +1 more source

When Acarbose Overdose Turns Severe: Managing Hypoglycemia in an Uncommon Scenario [PDF]

Clinical Case Reports
Acarbose is usually safe, but overdose can trigger severe, life‐threatening hypoglycemia. In cases of unexplained low blood sugar—particularly in patients with psychiatric illness or access to hypoglycemic drugs—acarbose toxicity should be considered ...
Aron Shrestha, Navin Poudel, Kshitiz Acharya, Arjun Chaudhary, Manish Acharya, Santosh Bastola, Bibek Ghimire   +6 more
doaj   +2 more sources