Results 1 to 10 of about 18,511 (201)

The 4-α-Glucanotransferase AcbQ Is Involved in Acarbose Modification in Actinoplanes sp. SE50/110

Microorganisms, 2023
The pseudo-tetrasaccharide acarbose, produced by Actinoplanes sp. SE50/110, is a α-glucosidase inhibitor used for treatment of type 2 diabetes patients.
Sophia Nölting, Camilla März, Lucas Jacob, Marcus Persicke, Susanne Schneiker-Bekel, Jörn Kalinowski   +5 more
doaj   +2 more sources

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

Synthetic and Systems Biotechnology
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found
Qianjin Kang, Xin Zhang
exaly   +3 more sources

The efficacy and tolerability of intermittent prandial acarbose to reduce glucose spikes in healthy individuals

Translational Medicine of Aging, 2023
Acarbose is an α-glucosidase inhibitor that slows the digestion of carbohydrates and can prevent sharp increases in blood sugar levels after meals (spikes).
A. Isman, A. Nyquist, M. Moel, X. Zhang, S. Zalzala   +4 more
doaj   +1 more source

Enhanced acarbose production by Streptomyces M37 using a two-stage fermentation strategy. [PDF]

PLoS ONE, 2017
In this work, we investigated the effect of pH on Streptomyces M37 growth and its acarbose biosynthesis ability. We observed that low pH was beneficial for cell growth, whereas high pH favored acarbose synthesis. Moreover, addition of glucose and maltose
Fei Ren, Long Chen, Shuangli Xiong, Qunyi Tong   +3 more
doaj   +1 more source

Theoretical Studies for the Discovery of Potential Sucrase-Isomaltase Inhibitors from Maize Silk Phytochemicals: An Approach to Treatment of Type 2 Diabetes

Molecules, 2023
A theoretical analysis of the potential inhibition of human sucrase-isomaltase (SI) by flavonoids was carried out with the aim of identifying potential candidates for an alternative treatment of type 2 diabetes. Two compounds from maize silks, maysin and
Linda-Lucila Landeros-Martínez, Mara Ibeth Campos-Almazán, Nora-Aydeé Sánchez-Bojorge, Raul Flores, Juan Pedro Palomares-Báez, Luz María Rodríguez-Valdez   +5 more
doaj   +1 more source

Alpha-Glucosidase Inhibitors Alter Gut Microbiota and Ameliorate Collagen-Induced Arthritis

Frontiers in Pharmacology, 2020
Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that acarbose influences the gut microbiota to affect the course of arthritis and tested this hypothesis in a collagen-induced arthritis (CIA) murine model. Acarbose in
Lingshu Zhang, Lingshu Zhang, Lingshu Zhang, Pingfang Song, Xiaowei Zhang, Christina Metea, Matthew Schleisman, Lisa Karstens, Eric Leung, Jun Zhang, Qiang Xu, Qiang Xu, Yi Liu, Mark Asquith, Cong-Qiu Chu, Cong-Qiu Chu   +15 more
doaj   +1 more source

Structural Insight into a Yeast Maltase—The BaAG2 from Blastobotrys adeninivorans with Transglycosylating Activity

Journal of Fungi, 2021
An early-diverged yeast, Blastobotrys (Arxula) adeninivorans (Ba), has biotechnological potential due to nutritional versatility, temperature tolerance, and production of technologically applicable enzymes. We have biochemically characterized from the Ba
Karin Ernits, Christian Kjeldsen, Karina Persson, Eliis Grigor, Tiina Alamäe, Triinu Visnapuu   +5 more
doaj   +1 more source

Acarbose for Postprandial Hypotension With Glucose Metabolism Disorders: A Systematic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine, 2021
Background: Postprandial hypotension (PPH) is an independent predictive factor of all-cause mortality in older people. Drug management has not achieved a satisfactory effect yet.
Biqing Wang, Biqing Wang, Junnan Zhao, Qiuxiao Zhan, Rongyanqi Wang, Birong Liu, Yan Zhou, Fengqin Xu   +7 more
doaj   +1 more source

α-Glucosidase-Mediated Glucometer Readout for Portable Monitoring of Acarbose and Migliol

Chemosensors, 2022
The α-glucosidase inhibitor is regarded as one of the most important drugs for the treatment of diabetes, which can control postprandial blood glucose levels via prolonging the carbohydrate digestion time and retarding the carbohydrates’ absorption.
Hao Zhang, Feng-Qing Yang
doaj   +1 more source

The Safety and Efficacy of Rosa Damascena Extract in Patients with Type II Diabetes: preliminary Report of a Triple Blind Randomized Acarbose Controlled Clinical Trial [PDF]

Journal of Kerman University of Medical Sciences, 2019
Background: Diabetes is a global health problem that its prevalence is increasing rapidly. Rosa damascena extract has shown to have an intensive non-competitive inhibitory effect on α-glucosidase in an animal study.
Mojgan Sanjari, Ahmad Gholamhoseinian Najar, Gholamreza asadikaram, mahboubeh mashayekhi, Amirfarhad Ghaseminejad Tafreshi   +4 more
doaj   +1 more source