Results 41 to 50 of about 19,411 (194)

Clinical features of pneumatosis intestinalis induced by alpha- glucosidase inhibitor in patients with type 2 diabetes mellitus: a single center retrospective study

Frontiers in Endocrinology
PurposePneumatosis intestinalis (PI) is a rare but significant side effect associated with the use of alpha-glucosidase inhibitor (αGI) in the treatment of diabetes.
Guanlin Wu, Weiheng He, Huimin Rao, Lin Lu, Xinran He, Xuewen Hou   +5 more
doaj   +1 more source

Acute Effects of Acarbose and Canagliflozin, Alone and in Combination, on Postprandial GLP‐1 and Glycaemic Responses in Post‐Bariatric Hypoglycaemia: A Randomised Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To evaluate the acute effects of acarbose and canagliflozin, alone and in combination, on postprandial total GLP‐1 and glycaemic responses during a mixed meal test in adults with post‐bariatric hypoglycaemia (PBH). Materials and Methods This single‐centre, randomised, four‐period crossover physiological study included 12 adults with PBH ...
Wei Yang, Anna Kowalka, Lara Jimenez‐Pacheco, Veronica Greener, Kleopatra Alexiadou, Ahmed Ahmed, Julia Kenkre, Chioma Izzi‐Engbeaya, Saira Hameed, Harvinder Chahal, Bernard Khoo, Tricia M.‐M. Tan   +11 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Long-term improvement of metabolic control by acarbose in type 2 diabetes patients poorly controlled with maximum sulfonylurea therapy

, 2003
Background and objective: Multiple oral therapies are required long term for the majority of patients with type 2 diabetes mellitus to achieve acceptable glycaemic levels; alternatively, insulin therapy has to be initiated.
Bachmann, W, Westermeier, T, Wascher, T, Petzinna, D, Raptis, SA, European Acarbose Study Grp   +5 more
core   +1 more source

Reconstruction and in silico analysis of an Actinoplanes sp. SE50/110 genome-scale metabolic model for acarbose production

Frontiers in Microbiology, 2015
Actinoplanes sp. SE50/110 produces the -glucosidase inhibitor acarbose, which is used to treat type 2 diabetes mellitus. To obtain a comprehensive understanding of its cellular metabolism, a genome-scale metabolic model of strain SE50/110, iYLW1028, was
Yali eWang, Yali eWang, Yali eWang, Nan eXu, Nan eXu, Chao eYe, Chao eYe, Liming eLiu, Liming eLiu, Zhongping eShi, Zhongping eShi, Jing eWu, Jing eWu   +12 more
doaj   +1 more source

Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights [PDF]

Chem Biodivers
Phytochemical and biological profiling of Launaea mucronata aerial parts reveals six bioactive constituents alongside potent antioxidant and antidiabetic properties. The hydroethanolic extract inhibits key carbohydrate‐metabolizing enzymes and exerts marked hypoglycemic and insulinotropic effects with histological restoration of metabolic organs in ...
Mohamed A, El Amir D, Abdel‐Fattah M, Zaki M, Mohammed R, Hassan M.   +5 more
europepmc   +2 more sources

Faecal Microbial and Metabolic Profiles Covary With Dietary Plant Composition in Tibetan Sheep Across Contrasting Grasslands

Environmental Microbiology Reports, Volume 18, Issue 6, December 2026.
Contrasting alpine meadow and desert steppe environments were associated with coordinated shifts in Tibetan sheep dietary plant composition, faecal bacterial communities and metabolites. Plant‐family composition was more strongly associated with microbial variation than dietary alpha diversity, while major metabolite differences involved flavonoid‐ and
He Ding, Nan Liu, Linyao Chen, Zenghui Liu, Wentao Zhang, Fangyu Gao, Kenan Li, Hai Wang, Jianshuang Wu, Xiaoqing Zhang   +9 more
wiley   +1 more source

ntMGAM-acarbose interactions.

, 2013
Schematic representation of interactions (dotted lines) between the ntMGAM side chain residues and acarbose. (PDB entry 2QMJ).
Qian Shang (445048), Junfeng Xiang (140276), Yalin Tang (140285), Hong Zhang (25820), Qian Li (114642)   +4 more
core   +1 more source

Use of Glucose‐Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11086-11094, December 2026.
ABSTRACT Aims Care home admission often reflects frailty and limited life expectancy, potentially altering the benefit‐harm balance of glucose‐lowering drug (GLD) treatment for type 2 diabetes (T2D). Real‐world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents.
Hanin Harbi, Reimar W. Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård   +7 more
wiley   +1 more source

Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study

Journal of Diabetes Research, 2014
Objective. To investigate the potential benefits of acarbose treatment on cardiovascular disease (CVD) in patients with type 2 diabetes by using nationwide insurance claim dataset. Research Design and Methods.
Jui-Ming Chen, Cheng-Wei Chang, Ying-Chieh Lin, Jorng-Tzong Horng, Wayne H.-H. Sheu   +4 more
doaj   +1 more source