Results 61 to 70 of about 18,511 (201)

Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 10, Page 1954-1967, October 2026.
Abstract BACKROUND The pseudo‐fruit of Rosa canina L. is a rich source of bioactive compounds with antioxidant, anti‐inflammatory, anti‐cancer, anti‐diabetic, anti‐aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra ...
Zafeiria Lemoni, Styliani Kalantzi, Theopisti Lymperopoulou, Andromachi Tzani, Georgios Stavropoulos, Anastasia Detsi, Diomi Mamma   +6 more
wiley   +1 more source

Bio‐guided fractionation of (9Z )‐5,8,11‐trihydroxyoctadec‐9‐enoic acid from Abelmoschus sagittifolius root as a potent α‐glucosidase inhibitor: An integrated in vitro and in silico study

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7735-7746, October 2026.
Abstract BACKGROUND Abelmoschus sagittifolius stands out as a valuable medicinal source for developing functional food targeting type 2 diabetes. This study investigated the α‐glucosidase inhibitory potential of an active fraction obtained from A. sagittifolius roots (ASR), enriched in (9Z)‐5,8,11‐trihydroxyoctadec‐9‐enoic acid (OA), using both enzyme ...
Nguyen Phuong Mai, Nguyen Van Quan, Nguyen Dang Duc, Tran Dang Xuan   +3 more
wiley   +1 more source

Antidiabetic Activity of an Ayurvedic Formulation Chaturmukha Rasa: A Mechanism Based Study

Journal of Pharmacopuncture, 2019
Objectives: The objective of this study was to evaluate antidiabetic activity of Chaturmukha rasa based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase ...
Akansha Sharma, Raj K Tiwari, Vikas Sharma, Ravindra K Pandey, Shiv Shnakar Shukla   +4 more
doaj   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

A Histomorphological Comparative Effects of Metformin, Pioglitazone, Repaglinide and Acarbose on Polycystic Ovary in Mice [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Polycystic ovary syndrome (PCO) is one of the most common causes of infertility due to anovulatory in women. The use of insulin-sensitizing agents was one of the treatments for this syndrome.
fariba noori, paria parto, mehri azadbakht, hamid darvishnia   +3 more
doaj  

Effect of Medications for Type 2 Diabetes on Cardiovascular Events and Mortality: A Comprehensive Pairwise and Network Meta‐Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9403-9411, October 2026.
ABSTRACT Aim To assess the effect of all the approved classes of medications for type 2 diabetes on Major Adverse Cardiovascular events (MACE) and all‐cause mortality. Methods We performed a pairwise and network meta‐analysis, including randomised controlled trials with a duration of at least 40 weeks, comparing medications versus placebo or an active ...
Giovanni Antonio Silverii, Valerio Velardi, Christian Marinelli, Antonino Lax, Matteo Monami, Edoardo Mannucci   +5 more
wiley   +1 more source

Comparative Analysis of Chemical Composition and Bioactivities of Essential Oils From Different Parts of Wild‐Grown Alpinia siamensis K.Schum. in Vietnam

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The essential oils of Alpinia siamensis are rich in β‐bisabolene, 1,8‐cineole, and β‐pinene. These essential oils inhibit α‐amylase and tyrosinase and also suppress the growth of Escherichia coli and Bacillus subtilis. ABSTRACT This study investigated chemical composition and bioactivities of essential oils (EOs) obtained from the rhizomes (REO ...
Nguyen Thi Kim Anh, Trang H. D. Nguyen, Tran Thi Huyen, Le Nhat Tam, Dang Ngoc Phuc, Anh Tu Phan, Le Duc Giang, Duong Chi, Nguyen Thi Ngan   +8 more
wiley   +1 more source

Safety and efficacy of acarbose in the treatment of diabetes in Chinese patients

, 2014
Ke He*, Jun-Cheng Shi*, Xiao-Ming Mao Department of Endocrinology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China *These authors contributed equally to this work Abstract: Acarbose is an α
Mao XM, Shi JC, He K
core  

ntMGAM-acarbose interactions.

, 2013
Schematic representation of interactions (dotted lines) between the ntMGAM side chain residues and acarbose. (PDB entry 2QMJ).
Qian Shang (445048), Junfeng Xiang (140276), Yalin Tang (140285), Hong Zhang (25820), Qian Li (114642)   +4 more
core   +1 more source

Comparison of medical resources and costs among patients with coronary heart disease and impaired glucose tolerance in the Acarbose Cardiovascular Evaluation trial

Journal of Diabetes
Background The Acarbose Cardiovascular Evaluation (ACE) trial (ISRCTN91899513) evaluated the alpha‐glucosidase inhibitor acarbose, compared with placebo, in 6522 patients with coronary heart disease and impaired glucose tolerance in China and showed a ...
Liam Mc Morrow, Frauke Becker, Ruth L. Coleman, Hertzel C. Gerstein, Lars Rydén, Stefan Schöder, Alastair M. Gray, Jose Leal, Rury R. Holman, for the ACE Study Group   +9 more
doaj   +1 more source