Results 21 to 30 of about 19,411 (194)

Drugs for diabetes: part 4 acarbose

, 2011
Acarbose is an alpha-glucosidase inhibitor acting in the gastrointestinal tract producing modest reductions in postprandial hyperglycaemia, with negligible risk of hypoglycaemia and weight gain.
Arungarinathan, Ganesan, Fisher, Miles, McKay, Gerard A.   +2 more
core   +6 more sources

Evaluation of Pharmaceutical Compatibility between Acarbose and Common Excipients Used in the Development of Controlled Release Formulations [PDF]

Pharmaceutical Sciences, 2021
Background: Excipients are used in the formulation of pharmaceutical dosage forms, but mayinteract with active pharmaceutical ingredients (APIs). Some of these interactions could alterthe physicochemical properties of the APIs which can affect the ...
Aiesheh Gholizadeh-Hashjin, Mohammad Shabani, Farnaz Monajjemzadeh   +2 more
doaj   +1 more source

Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria

, 2023
Acarbose is a well-known microbial specialized metabolite used clinically to treat type 2 diabetes. This natural pseudo-oligosaccharide (PsOS) shows potent inhibitory activity toward various glycosyl hydrolases, including α-glucosidases and α-amylases ...
Samuel Tanoeyadi (14438266), Takuya Ito (57473), Samuel Tanoeyadi, Benjamin Philmus (1357395), Taifo Mahmud (307800), Takeshi Tsunoda (8124896), Takeshi Tsunoda, Benjamin Philmus, Takuya Ito, Taifo Mahmud   +9 more
core   +1 more source

A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults

BMC Geriatrics, 2019
Background Postprandial hypotension (PPH) occurs frequently in the elderly and patients with type 2 diabetes, and lacks a satisfactory treatment. Gastric distension and the α-glucosidase inhibitor, acarbose, may attenuate the postprandial fall in blood ...
Hung Pham, Laurence Trahair, Liza Phillips, Christopher Rayner, Michael Horowitz, Karen Jones   +5 more
doaj   +1 more source

In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose

Molecules, 2011
The inhibitory activity on pancreatic α-amylase by cyanidin-3-rutinoside was examined in vitro. The IC50 value of cyanidin-3-rutinoside against pancreatic α-amylase was 24.4 ± 0.1 μM.
Sarinya Akkarachiyasit, Sirintorn Yibchok-Anun, Sumrit Wacharasindhu, Sirichai Adisakwattana   +3 more
doaj   +1 more source

Studies on the ecological functions of the antidiabetic drugs acarbose

Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature.
Tanoeyadi, Samuel
core   +4 more sources

The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity

Cell Reports Medicine
Summary: Inflammation is critical for obesity and obesity-induced insulin resistance (IR). In this study, we reveal the function and mechanism of acarbose on adipose tissue macrophage (ATM)-mediated inflammation in obesity and obesity-induced IR.
Xiaohui Li, Shimeng Zheng, Haozhe Xu, Zihan Zhang, Xiaotong Han, Yunxiong Wei, Hua Jin, Xiaonan Du, Hufeng Xu, Mengyi Li, Zhongtao Zhang, Songlin Wang, Guangyong Sun, Dong Zhang   +13 more
doaj   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Presence of Isorhamnetin-3-O-Rutinoside Enhances Interaction of Acarbose With α-Amylase/α-Glucosidase

Journal of Spectroscopy
Studies indicated that some active flavonoids combined with acarbose could reduce the side effects of acarbose and enhance its efficacy. Isorhamnetin-3-O-rutinoside (IOR) is a flavonoid found in many edible herbs. In this work, the synergistic effects of
Xue Zhang, Di Lian, Yuan Li, Yutong Du, Zihan Qu, YuXin Cui, Li Li   +6 more
doaj   +1 more source

A randomized controlled trial comparing acarbose vs. insulin therapy for gestational diabetes in individuals with inadequate glycemic control by diet alone

Clinical and Experimental Obstetrics & Gynecology, 2020
Introduction: Gestational diabetes (GD) is one of the most common medical complications of pregnancy, associated with increased incidence of pre-eclampsia, macrosomia, and cesarean delivery.
J. A. Villarreal-Rodriguez, L. G. Mancillas Adame, J. Maldonado-Sanchez, A. Guzmán-López, O. R. Treviño-Montemayor, J. G. Gonzalez-Gonzalez, D. Saldívar-Rodríguez   +6 more
doaj   +1 more source