Results 21 to 30 of about 16,949 (211)

A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults

BMC Geriatrics, 2019
Background Postprandial hypotension (PPH) occurs frequently in the elderly and patients with type 2 diabetes, and lacks a satisfactory treatment. Gastric distension and the α-glucosidase inhibitor, acarbose, may attenuate the postprandial fall in blood ...
Hung Pham, Laurence Trahair, Liza Phillips, Christopher Rayner, Michael Horowitz, Karen Jones   +5 more
doaj   +1 more source

Improved glycemic control by acarbose therapy in hypertensive diabetic patients: effects on blood pressure and hormonal parameters

Brazilian Journal of Medical and Biological Research, 2002
A double-blind, randomized, placebo-controlled study was carried out on 44 hypertensive type 2 diabetic subjects previously treated by diet associated or not with sulfonylurea to assess the effects of acarbose-induced glycemic control on blood pressure ...
P. Rosenbaum, R.B. Peres, M.T. Zanella, S.R.G. Ferreira   +3 more
doaj   +1 more source

Reconstruction and in silico analysis of an Actinoplanes sp. SE50/110 genome-scale metabolic model for acarbose production

Frontiers in Microbiology, 2015
Actinoplanes sp. SE50/110 produces the -glucosidase inhibitor acarbose, which is used to treat type 2 diabetes mellitus. To obtain a comprehensive understanding of its cellular metabolism, a genome-scale metabolic model of strain SE50/110, iYLW1028, was
Yali eWang, Yali eWang, Yali eWang, Nan eXu, Nan eXu, Chao eYe, Chao eYe, Liming eLiu, Liming eLiu, Zhongping eShi, Zhongping eShi, Jing eWu, Jing eWu   +12 more
doaj   +1 more source

Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria

, 2023
Acarbose is a well-known microbial specialized metabolite used clinically to treat type 2 diabetes. This natural pseudo-oligosaccharide (PsOS) shows potent inhibitory activity toward various glycosyl hydrolases, including α-glucosidases and α-amylases ...
Samuel Tanoeyadi (14438266), Takuya Ito (57473), Samuel Tanoeyadi, Benjamin Philmus (1357395), Taifo Mahmud (307800), Takeshi Tsunoda (8124896), Takeshi Tsunoda, Benjamin Philmus, Takuya Ito, Taifo Mahmud   +9 more
core   +1 more source

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110

, 2012
Schwientek P, Szczepanowski R, Rückert C, et al. The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. BMC Genomics. 2012;13(1): 112.Background Actinoplanes sp.
Szczepanowski, Rafael, Kalinowski Jörn, Rückert Christian, Selber, Klaus, Udo F Wehmeier, Christian Ruckert, Jorn Kalinowski, Jens Stoye, Wehmeier Udo F, Pühler Alfred, Stoye, Jens ; https://orcid.org/, Kalinowski, Jörn, Selber Klaus, Stoye Jens, Klein, Andreas, Klaus Selber, Alfred Puhler, Pühler, Alfred ; https://orcid.org/, Schwientek, Patrick, Schwientek Patrick, Szczepanowski Rafael, Rückert, Christian ; https://orcid.org/, Rafael Szczepanowski, Patrick Schwientek, Andreas Klein, Wehmeier, Udo F., Klein Andreas   +26 more
core   +1 more source

Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

Microbial Cell Factories, 2022
Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain.
Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang, Shaoxin Chen   +6 more
doaj   +1 more source

Acarbose Treatment and the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study

Journal of Diabetes Research, 2014
Objective. To investigate the potential benefits of acarbose treatment on cardiovascular disease (CVD) in patients with type 2 diabetes by using nationwide insurance claim dataset. Research Design and Methods.
Jui-Ming Chen, Cheng-Wei Chang, Ying-Chieh Lin, Jorng-Tzong Horng, Wayne H.-H. Sheu   +4 more
doaj   +1 more source

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients

, 2016
Flavio A Cadegiani,1 Osvalmir Sá Silva2 1Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 2Corpometria Institute, an Obesity and ...
Cadegiani FA, Silva, Osvalmir Sa, Silva OS, Cadegiani, Flavio A. [UNIFESP]   +3 more
core   +1 more source

The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity

Cell Reports Medicine
Summary: Inflammation is critical for obesity and obesity-induced insulin resistance (IR). In this study, we reveal the function and mechanism of acarbose on adipose tissue macrophage (ATM)-mediated inflammation in obesity and obesity-induced IR.
Xiaohui Li, Shimeng Zheng, Haozhe Xu, Zihan Zhang, Xiaotong Han, Yunxiong Wei, Hua Jin, Xiaonan Du, Hufeng Xu, Mengyi Li, Zhongtao Zhang, Songlin Wang, Guangyong Sun, Dong Zhang   +13 more
doaj   +1 more source

In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose

Molecules, 2011
The inhibitory activity on pancreatic α-amylase by cyanidin-3-rutinoside was examined in vitro. The IC50 value of cyanidin-3-rutinoside against pancreatic α-amylase was 24.4 ± 0.1 μM.
Sarinya Akkarachiyasit, Sirintorn Yibchok-Anun, Sumrit Wacharasindhu, Sirichai Adisakwattana   +3 more
doaj   +1 more source