Results 21 to 30 of about 25,530 (233)

Trapping and Characterization of the Reaction Intermediate in Cyclodextrin Glycosyltransferase by Use of Activated Substrates and a Mutant Enzyme [PDF]

, 1997
Cyclodextrin glycosyltransferases (CGTases) catalyze the degradation of starch into linear or cyclic oligosaccharides via a glycosyl transfer reaction occurring with retention of anomeric configuration.
Dijkstra, Bauke W.,, He, Shouming,, Mosi, Renee,, Uitdehaag, Joost,, Withers, Stephen G.,   +4 more
core   +3 more sources

The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome

mSphere, 2019
Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the
Nielson T. Baxter, Nicholas A. Lesniak, Hamide Sinani, Patrick D. Schloss, Nicole M. Koropatkin   +4 more
doaj   +1 more source

In Silico Study of a-Amylase and a-Glucosidase Inhibitory Compounds in Aloe vera as Antidiabetic Agent

Biotropika: Journal of Tropical Biology, 2023
Type 2 diabetes mellitus (T2DM) is a chronic disease that poses a significant global health issue. The most commonly given drug to treat diabetes is acarbose, which works as an inhibitor of polysaccharide-degrading enzymes, such as alpha amylase dan ...
M. Nizam Zulfi Zakaria, Ahmad Fariduddin Aththar, Syeftyan Muhammad Ali Hamami, Michelle Fai, Sri Rahayu   +4 more
doaj   +1 more source

A randomized, crossover study of the acute effects of acarbose and gastric distension, alone and combined, on postprandial blood pressure in healthy older adults

BMC Geriatrics, 2019
Background Postprandial hypotension (PPH) occurs frequently in the elderly and patients with type 2 diabetes, and lacks a satisfactory treatment. Gastric distension and the α-glucosidase inhibitor, acarbose, may attenuate the postprandial fall in blood ...
Hung Pham, Laurence Trahair, Liza Phillips, Christopher Rayner, Michael Horowitz, Karen Jones   +5 more
doaj   +1 more source

Evaluation of the effects of acarbose on weight and metabolic, inflammatory, and cardiovascular markers in patients with obesity and overweight

International Journal of Preventive Medicine, 2020
Background: Metabolic syndrome (MetS) refers to a cluster of risk factors for cardiovascular disease and type 2 diabetes. The aim of this study is to assess the effects of acarbose as an antihyperglycemic agent (drug) on late complications of MetS ...
Noushin Khalili, Alireza Safavipour
doaj   +1 more source

Pharmacological Treatment of Postprandial Reductions in Blood Pressure : A Systematic Review [PDF]

, 2015
Funded by The Dunhill Medical Trust.
Alam, Aronow, Freeman, Gentilcore, Heseltine, Heseltine, Hirayama, Jansen, Jansen, Jansen, Jansen, Jian, Jones, Jones, Lenders, Lipsitz, Lipsitz, Moher, O'Donovan, Onrot, Potter, Rakic, Russo, Sawynok, Shibao, Vaitkevicius, Visvanathan, Vloet, Vloet   +28 more
core   +1 more source

Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Level in SD Rats Model [PDF]

, 2013
This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of ...
Apostolidis, Emmanouil, Ha, Kyoung-Soo, Jo, Sung-Hoon, Kim, Jong-Gwan, Kim, Young-Cheul, Kwon, Young-In, Moon, Kyoung-Sik, Oh, Chen-Gum   +7 more
core   +3 more sources

A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle [PDF]

, 2013
Peer reviewedPublisher ...
Bestwick, Charles, Cruickshank, Morven, Hoggard, Nigel, Holst, Jens J, Horgan, Graham, Moar, Kim-Marie, Russell, Wendy   +6 more
core   +1 more source

The influence of in vitro gastrointestinal digestion on the chemical composition and antioxidant and enzyme inhibitory capacities of carob liqueurs obtained with different elaboration techniques [PDF]

, 2019
Carob liqueur is a traditional Mediterranean alcoholic beverage obtained via a wide range of production techniques contributing to the different organoleptic attributes of the final product.
Coelho, Natacha, Gonçalves, Sandra, Pérez-Santín, Efrén, Rodríguez Solana, Raquel, Romano, Anabela, Santos-Rufo, Antonio   +5 more
core   +1 more source

Reconstruction and in silico analysis of an Actinoplanes sp. SE50/110 genome-scale metabolic model for acarbose production

Frontiers in Microbiology, 2015
Actinoplanes sp. SE50/110 produces the -glucosidase inhibitor acarbose, which is used to treat type 2 diabetes mellitus. To obtain a comprehensive understanding of its cellular metabolism, a genome-scale metabolic model of strain SE50/110, iYLW1028, was
Yali eWang, Yali eWang, Yali eWang, Nan eXu, Nan eXu, Chao eYe, Chao eYe, Liming eLiu, Liming eLiu, Zhongping eShi, Zhongping eShi, Jing eWu, Jing eWu   +12 more
doaj   +1 more source