Results 11 to 20 of about 19,411 (194)

Acarbose glycosylation by AcbE for the production of acarstatins with enhanced α-amylase inhibitory activity

open access: yesSynthetic and Systems Biotechnology
Acarbose is a potent glycosidase inhibitor widely used in the clinical treatment of type 2 diabetes mellitus (T2DM). Various acarbose analogs have been identified while exploring compounds with improved pharmacological properties. In this study, we found
Xin Zhang   +5 more
doaj   +2 more sources

The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome

open access: yesmSphere, 2019
Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the
Nielson T. Baxter   +4 more
doaj   +2 more sources

MARCH2: comparative assessment of therapeutic effects of acarbose and metformin in newly diagnosed type 2 diabetes patients. [PDF]

open access: yesPLoS ONE, 2014
The data of MARCH (Metformin and AcaRbose in Chinese as the initial Hypoglycaemic treatment) trial demonstrated that acarbose and metformin have similar efficacy as initial therapy for hemoglobin A1c (HbA1c) reduction in Chinese patients with newly ...
Guang Wang   +6 more
doaj   +2 more sources

Improved glycemic control by acarbose therapy in hypertensive diabetic patients: effects on blood pressure and hormonal parameters [PDF]

open access: yesBrazilian Journal of Medical and Biological Research, 2002
A double-blind, randomized, placebo-controlled study was carried out on 44 hypertensive type 2 diabetic subjects previously treated by diet associated or not with sulfonylurea to assess the effects of acarbose-induced glycemic control on blood pressure ...
P. Rosenbaum   +3 more
doaj   +2 more sources

Acarbose

open access: yesReactions Weekly
INTRODUCTION/BACKGROUNDReactive hypoglycemia, or postprandial hypoglycemia, which can occur during pregnancy due to physiological changes such as altered insulin sensitivity and heightened metabolic needs, presents unique management considerations.
Nurbadriah Jasmiad, Shartiyah Ismail
  +5 more sources

Gene Cascade Shift and Pathway Enrichment in Rat Kidney Induced by Acarbose Through Comparative Analysis

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Acarbose is an effective anti-diabetic drug to treat type 2 diabetes mellitus (T2DM), a chronic degenerative metabolic disease caused by insulin resistance. The beneficial effects of acarbose on blood sugar control in T2DM patients have been confirmed by
Chun-Yue Weng   +20 more
doaj   +1 more source

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110 [PDF]

open access: yes, 2012
Schwientek P, Szczepanowski R, Rückert C, et al. The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. BMC Genomics. 2012;13(1): 112.Background Actinoplanes sp.
Szczepanowski, Rafael   +26 more
core   +1 more source

Evaluation of the effects of acarbose on weight and metabolic, inflammatory, and cardiovascular markers in patients with obesity and overweight

open access: yesInternational Journal of Preventive Medicine, 2020
Background: Metabolic syndrome (MetS) refers to a cluster of risk factors for cardiovascular disease and type 2 diabetes. The aim of this study is to assess the effects of acarbose as an antihyperglycemic agent (drug) on late complications of MetS ...
Noushin Khalili, Alireza Safavipour
doaj   +1 more source

In Silico Study of a-Amylase and a-Glucosidase Inhibitory Compounds in Aloe vera as Antidiabetic Agent

open access: yesBiotropika: Journal of Tropical Biology, 2023
Type 2 diabetes mellitus (T2DM) is a chronic disease that poses a significant global health issue. The most commonly given drug to treat diabetes is acarbose, which works as an inhibitor of polysaccharide-degrading enzymes, such as alpha amylase dan ...
M. Nizam Zulfi Zakaria   +4 more
doaj   +1 more source

Acarbose promotes remission of both early and late dumping syndromes in post-bariatric patients [PDF]

open access: yes, 2016
Flavio A Cadegiani,1 Osvalmir Sá Silva2 1Division of Endocrinology and Metabolism, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, 2Corpometria Institute, an Obesity and ...
Cadegiani FA   +3 more
core   +1 more source

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