Results 41 to 50 of about 117,444 (264)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
“A call to action”: Schrödinger's representation of quantum mechanics via Hamilton's principle
, 2023 A few years ago, one of the former Editors of this journal launched "a call to action"(E. F. Taylor, Am. J. Phys. 71, 423-425 (2003)) for a revision of teaching methods in physics in order to emphasize the importance of the principle of least action.
Michele Marrocco, Marrocco M.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Pedagogical practices of physics teachers from the Catatumbo region, Colombia
, 2020 Pedagogical practice allows teachers to focus their attention on three types of knowledge: disciplinary knowledge: what do I know, pedagogical knowledge: how do I communicate what I know, and academic knowledge: how do I transform myself with what I ...
GALLARDO PÉREZ, HENRY DE JESÚS +2 more
core +1 more source
A unifying physically meaningful relativistic action
Scientific Reports, 2022 AbstractThe motion of an object under the influence of force fields and/or media is described by means of a world-line with least action in its influenced spacetime. For any spacetime point x and a four-vector u, measured in the frame of an inertial observer, a unifying and physically meaningful action function L(x, u) generating the action is defined.
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Group action in topos quantum physics [PDF]
Journal of Mathematical Physics, 2013 Topos theory has been suggested first by Isham and Butterfield, and then by Isham and Döring, as an alternative mathematical structure within which to formulate physical theories. In particular, it has been used to reformulate standard quantum mechanics in such a way that a novel type of logic is used to represent propositions. In this paper, we extend
openaire +2 more sources