Results 71 to 80 of about 117,444 (264)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Improving the Training of Pre-Service Physics Teachers in Malaysia using Didaktik Analysis
, 2008 The research in this thesis examined the use of a didaktik-based approach to thinking about teaching and learning to the training of pre-service physics teachers in a Malaysian teacher training programme.
Ishak, Mohd. Zaki
core
Physics of F-theory compactifications without section [PDF]
, 2014 We study the physics of F-theory compactifications on genus-one fibrations without section by using an M-theory dual description. The five-dimensional action obtained by considering M-theory on a Calabi-Yau threefold is compared with a six-dimensional F ...
Keitel, Jan +7 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2015 This is a textbook that derives the fundamental theories of physics from symmetry. It starts by introducing, in a completely self-contained way, all mathematical tools needed to use symmetry ideas in physics. Thereafter, these tools are put into action
Schwichtenberg, Jakob
core +1 more source
Action research for physics case studies
, 2012 This case study booklet was produced as part of the evaluation of the Action Research for Physics (ARP) teacher professional development programme which was organised and managed by the nine Regional Science Learning Centres between September 2009 and ...
Grace, Marcus, Garrett, Caro
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Generating emergent physics for action-adventure games
, 2012 Action-adventure games typically integrate levels, progres-sion with the physical gameplay. In order to generate con-tent for this type of games, this paper explores how pro-cedural techniques can be expanded to beyond the domain of generating levels ...
Joris Dormans
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source