Results 81 to 90 of about 1,172,088 (296)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Labpunk - Curiosity, Intra-action and Creativeness in a Physics-art Collaboration

Transformations, 2015
Artistically and scientifically, we see potential for experimentation and discovery in the artefacts of physics – in bits of lab equipment, experimental results and theoretical models – for the creation of original works of art which may be worn as ...
AK Milroy, MJ Wegener, Am Holmes
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Thermodynamics of the most generalized form of holographic dark energy and some particular cases with corrected entropies

Nuclear Physics B
A four-parameter generalized entropy has recently been developed based on the generalized cut-off of holographic dark energy (HDE) formalism. It reduces to various known entropies for appropriate parameter limits, as shown in recent studies by Odintsov ...
Sanghati Saha, Ertan Güdekli, Surajit Chattopadhyay, Gizem Dilara Açan Yildiz   +3 more
doaj   +1 more source

Penerapan Program Crocodile Physics Sebagai Media Pembelajaran dalam Upaya Meningkatkan Pemahaman Konsep Fisika Siswa

Indonesian Journal of Science and Mathematics Education, 2019
:Research In this journal aims to find out the increasing students in understanding the conception of physics through the help of media Crocodile Physics programs. The form of research used in this study is Action Research.
Abdi Novianto, Nirva Diana
doaj   +1 more source

Towards an effective-action approach to fermion-loop corrections

, 2003
We present a study of the effective action approach to incorporate higher-order effects in e^+e^- -> n fermions. In its minimal version, the effective action approach is found to exhibit problems with unitarity and high-energy behaviour.
Beenakker, W., Chapovsky, A. P., Kanaki, A., Papadopoulos, C. G., Pittau, R.   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A compact stellar configuration via gravitation decoupling and minimal geometric deformation

Nuclear Physics B
The present study reports an investigation of a minimally deformed solution from class one solution embedded into five-dimensional pseudo-Euclidean space, which is the four-dimensional space-time, through a gravitational decoupling approach. Applying the
Samprity Das, Surajit Chattopadhyay, Ertan Güdekli   +2 more
doaj   +1 more source

Dynamical Aspects of Analogue Gravity: The Backreaction of Quantum Fluctuations in Dilute Bose-Einstein Condensates

, 2007
We discuss the backreaction force exerted by quantum fluctuations in dilute Bose-Einstein condensates onto the motion of the classical background, derived by an ab initio approach from microscopic physics.
A. Griffin, A. Görlitz, A. J. Leggett, A. Trautman, C. Barceló, C. Barceló, C. Barceló, C. Barceló, D. Jaksch, E. H. Lieb, E. Madelung, E.P. Gross, F. Dalfovo, G. E. Volovik, H. Fröhlich, H. Minkowski, I. M. Khalatnikov, J. R. Anglin, L. Onsager, L. Pitaevskii, M. Girardeau, M. Olshanii, M. Stone, M. Visser, M. Visser, N. N. Bogoliubov, P. O. Fedichev, P. O. Fedichev, P. Painlevé, R. Balbinot, R. Schützhold, R. Schützhold, R. Schützhold, T. A. Jacobson, T. D. Lee, U. R. Fischer, U. R. Fischer, V. I. Yukalov, W. G. Unruh, W. G. Unruh, W. Gordon, Y. Castin, Y. Castin   +42 more
core   +1 more source