Results 81 to 90 of about 4,571,499 (346)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Constraining the UV with the electroweak effective action

Journal of High Energy Physics
By considering an arbitrary bare action describing BSM physics, we use the Barvinsky-Vilkovisky resummation to obtain the most general non-local electroweak effective action at second order in the field strength.
Iberê Kuntz, Amanda Malagi
doaj   +1 more source

Machine learning action parameters in lattice quantum chromodynamics [PDF]

, 2018
Numerical lattice quantum chromodynamics studies of the strong interaction are important in many aspects of particle and nuclear physics. Such studies require significant computing resources to undertake.
P. Shanahan, D. Trewartha, W. Detmold
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Penerapan Program Crocodile Physics Sebagai Media Pembelajaran dalam Upaya Meningkatkan Pemahaman Konsep Fisika Siswa

Indonesian Journal of Science and Mathematics Education, 2019
:Research In this journal aims to find out the increasing students in understanding the conception of physics through the help of media Crocodile Physics programs. The form of research used in this study is Action Research.
Abdi Novianto, Nirva Diana
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Thermodynamics of the most generalized form of holographic dark energy and some particular cases with corrected entropies

Nuclear Physics B
A four-parameter generalized entropy has recently been developed based on the generalized cut-off of holographic dark energy (HDE) formalism. It reduces to various known entropies for appropriate parameter limits, as shown in recent studies by Odintsov ...
Sanghati Saha, Ertan Güdekli, Surajit Chattopadhyay, Gizem Dilara Açan Yildiz   +3 more
doaj   +1 more source

PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) UNTUK MENINGKATKAN HASIL BELAJAR FISIKA PADA POKOK BAHASAN GEJALA DAN CIRI CIRI GELOMBANG SISWA KELAS XII SMAN 9 PEKANBARU

Jurnal PAJAR (Pendidikan dan Pengajaran), 2017
This research is motivated by the lack of physics student learning outcomes on feature highlights feature of wave class XII SMAN 9 Pekanbaru. This study aims to improve the learning outcomes of physics students on feature highlights wave characteristics ...
Gustariani Gustariani
doaj   +1 more source