Results 161 to 170 of about 10,981,913 (333)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Incorporating suicide prevention in the WPA Action Plan 2023-2026. [PDF]

World Psychiatry
Wasserman D, Iosue M, Petros NG, Riblet N.   +3 more
europepmc   +1 more source

Youth crime action plan: update [PDF]

, 2010

core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Plan de Acción Action Plan

Revista Colombiana de Obstetricia y Ginecología, 2006
Hernando Gaitán D
doaj  

Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART). [PDF]

J Allergy Clin Immunol Glob
Bucha S, Kim H, Kareem K, Watridge C, Laker P, Clover A, Brownson RC, Chuahan K, Sumino K, Castro M, Huffman MD, Krings JG.   +11 more
europepmc   +1 more source

ICT future skills action plan [PDF]

, 2008

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Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Global Pandemic Has Shown We Need an Action Plan for the Ocean

Frontiers in Marine Science, 2021
Eugene J. Murphy, Carol Robinson, Alistair J. Hobday, Alistair J. Hobday, Alice Newton, Marion Glaser, Karen Evans, Mark Dickey-Collas, Mark Dickey-Collas, Stephanie Brodie, Marion Gehlen   +10 more
doaj   +1 more source

Jockey Club Age-Friendly City Project : Action plan : Tuen Mun

, 2017
In response to the global ageing population, the World Health Organization (the “WHO”) devised the concept of “Global Age-friendly Cities” in 2005 to encourage cities all around the world to develop a healthy and comfortable living environment with age ...
Asia-Pacific Institute of Ageing Studies, Lingnan University
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