Results 221 to 230 of about 12,692,953 (333)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. [PDF]

Sci Rep, 2016
Benz A, Kossack M, Auth D, Seyler C, Zitron E, Juergensen L, Katus HA, Hassel D.   +7 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Age-Dependent Increase in AF Cannot Be Explained by Shortening of Action Potential Duration

, 2022
Simon Pecha, Djemail Ismaili, Bastiaan Geelhoed, Michael Knaut, Hermann C. Reichenspurner, Thomas Eschenhagen, Renate B. Schnabel, Torsten Christ, Ursual Ravens   +8 more
openalex   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model. [PDF]

Sci Rep, 2019
Kim TY, Jeng P, Hwang J, Pfeiffer Z, Patel D, Cooper LL, Kossidas K, Centracchio J, Peng X, Koren G, Qu Z, Choi BR.   +11 more
europepmc   +1 more source

Nonlinear dynamics and chaos in fractional-order cardiac action potential duration mapping model with fixed memory length

Aida Bellout, Rabah Bououden, Tarek Houmor, Messaoud Berkal   +3 more
openalex   +2 more sources

Epicatechin Attenuated Vascular Dysfunction, Markers of Oxidative Stress, Hyperlipidemia and Decreased Cardiac Action Potential Duration in Middle-Aged Obese, Hypertensive Rat Models of Metabolic Syndrome

, 2022
Romeo Jr Batacan, Kylie Connolly, Douglas Jackson, Andrew Stuart Fenning   +3 more
openalex   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Editorial: Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias

Frontiers in Physiology, 2020
Peter Taggart, George E. Billman
doaj   +1 more source