Results 101 to 110 of about 772,376 (319)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Bio-realistic and versatile artificial dendrites made of anti-ambipolar transistors

Neuromorphic Computing and Engineering
The understanding of neural networks as neuron-synapse binaries has been the foundation of neuroscience, and therefore, the emerging neuromorphic computing technology that takes inspiration from the brain.
Yifei Yang, Mingkun Xu, Tianhang Zhang, Chenfei Miao, Juan Lyu, Jing Pei, Peng Li, Guoqi Li, Si Wu, Huanglong Li   +9 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Diverse Intrinsic Properties Shape Functional Phenotype of Low-Frequency Neurons in the Auditory Brainstem

Frontiers in Cellular Neuroscience, 2018
In the auditory system, tonotopy is the spatial arrangement of where sounds of different frequencies are processed. Defined by the organization of neurons and their inputs, tonotopy emphasizes distinctions in neuronal structure and function across ...
Hui Hong, Xiaoyu Wang, Xiaoyu Wang, Ting Lu, Diego A. R. Zorio, Diego A. R. Zorio, Yuan Wang, Yuan Wang, Jason Tait Sanchez, Jason Tait Sanchez, Jason Tait Sanchez   +10 more
doaj   +1 more source

Slow synaptic transmission in frog sympathetic ganglia [PDF]

, 1986
Bullfrog ganglia contain two classes of neurone, B and C cells, which receive different inputs and exhibit different slow synaptic potentials. B cells, to which most effort has been directed, possess slow and late slow EPSPs.
Adams, P. R., Brown, D. A., Jones, S. W., Koch, Christof, Lancaster, B., Pennefeather, P.   +5 more
core   +2 more sources

Twenty-four-micrometer-pitch microelectrode array with 6912-channel readout at 12 kHz via highly scalable implementation for high-spatial-resolution mapping of action potentials [PDF]

, 2017
Jun Ogi, Yuri Kato, Yoshihisa Matoba, Chigusa Yamane, Kazunori Nagahata, Yusaku Nakashima, Takuya Kishimoto, Shigeki Hashimoto, Koichi Maari, Yusuke Oike, Takayuki Ezaki   +10 more
openalex   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons

, 2003
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity.
A. Artola, B.L. Sabatini, C. Racca, C.E. Jahr, D.E. Feldman, D.E. Feldman, G. Bi, G. Carmignoto, G.C. Castellani, Gastone C. Castellani, H. Markram, H. Markram, H.D. Abarbanel, H.Z. Shouval, H.Z. Shouval, Harel Z. Shouval, J.A. Cummings, J.A. Lisman, J.C. Magee, Luk C. Yeung, M. Nishiyama, M.E. Larkum, M.F. Bear, M.F. Bear, N. Levy, P.J. Sjöström, R. Kempter, S. Song, S.M. Dudek, S.N. Yang, T. Kitajima, T.V.P. Bliss, U.R. Karmarkar, V.N. Murthy, W. Senn   +34 more
core   +1 more source

Sodium-Calcium Action Potential Associated With Contraction in the Heliozoan Actinocoryne Contractilis [PDF]

, 1986
Colette Febvre‐Chevalier, A. Bilbaut, Q. Bone, Jean Febvre   +3 more
openalex   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source