Results 131 to 140 of about 14,230,890 (402)

Information Encoding and Reconstruction from the Phase of Action Potentials

Frontiers in Systems Neuroscience, 2009
Fundamental questions in neural coding are how neurons encode, transfer, and reconstruct information from the pattern of action potentials (APs) exchanged between different brain structures.
Z. Nadasdy
semanticscholar   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Optimizing Optogenetic Activation of Purkinje Cell Axons to Investigate the Purkinje Cell – DCN Synapse

Frontiers in Synaptic Neuroscience, 2019
Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver, Kim M. Gruver, Alanna J. Watt   +2 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Efficacy of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) at the M1 Hotspot Versus C3 Site in Modulating Corticospinal Tract Excitability

Biomedicines
Previous studies have shown that beta-band transcranial alternating current stimulation (tACS) applied at the M1 hotspot can modulate corticospinal excitability.
Hao Meng, Michael Houston, Nicholas Dias, Chen Guo, Gerard Francisco, Yingchun Zhang, Sheng Li   +6 more
doaj   +1 more source

Noncommutative fluid dynamics in the K\"{a}hler parametrization

, 2011
In this paper, we propose a first order action functional for a large class of systems that generalize the relativistic perfect fluids in the K\"{a}hler parametrization to noncommutative spacetimes.
A. Connes, I. V. Vancea, L. Holender, M. A. Santos, M. Schlichenmaier, M. T. D. Orlando, N. Reshetikhin   +6 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

An electrophysiologist’s guide to dorsal horn excitability and pain

Frontiers in Cellular Neuroscience
The dorsal horn of the spinal cord represents the first site in the central nervous system (CNS) where nociceptive signals are integrated. As a result, there has been a rapid growth in the number of studies investigating the ionic mechanisms regulating ...
Iván Rivera-Arconada, Mark L. Baccei, José A. López-García, Rita Bardoni   +3 more
doaj   +1 more source

An improved effective potential for electroweak phase transitions

, 1994
It is shown that improved potentials and corrected mass terms can be introduced by using a quadratic source term in the path integral construction for the effective action.
A. Salam, B.S. DeWitt, D.A. Kirzhnits, G. Amelino-Camelia, G. Jona-Lasinio, Ian G. Moss, J. Goldstone, J.M. Cornwall, Janaki Balakrishnan, L. Dolan, M. Dine, M. Sher, M.E. Carrington, N.K. Nielsen, P. Arnold, S. Glashow, S. Weinberg, S. Weinberg, S.W. Hawking   +18 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source