Results 151 to 160 of about 4,325 (209)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The cost of an action potential
Journal of Neuroscience Methods, 2000Neuronal modules, or 'cell-assemblies', comprising millions of mutually interconnected cells have been postulated to form the basis of many functions of the brain, such as mood, sleep, hunger, vigilance, and more. Depending on the extent of the module, neurocommunication in cell-assemblies might exceed metabolic resources. A medium-size (10000 neurons)
G L, Aiello, P, Bach-y-Rita
openaire +2 more sources
Potentiation of Epinephrine Action
Nature, 1961THE following experimental results have been reported by our colleagues on the potentiation of epinephrine action by various substances, clarifying part of its mechanism : (1) The potentiation of epinephrine action on vasoconstriction by certain amino-acids was attributed to a reaction in which the oxidized form of epinephrine gave rise to the ...
R, IMAIZUMI, Y, HASHIMOTO, M, OKA
openaire +2 more sources
Neurobiology of Learning and Memory, 2000
Neurons compute in part by integrating, on a time scale of milliseconds, many synaptic inputs and generating a digital output-the "action potential" of classic electrophysiology. Recent discoveries indicate that neurons also perform a second, much slower, integration operating on a time scale of minutes or even hours.
openaire +2 more sources
Neurons compute in part by integrating, on a time scale of milliseconds, many synaptic inputs and generating a digital output-the "action potential" of classic electrophysiology. Recent discoveries indicate that neurons also perform a second, much slower, integration operating on a time scale of minutes or even hours.
openaire +2 more sources
New Progestins and Potential Actions
Journal of the Society for Gynecologic Investigation, 2000Newer, nonsteroidal, orally active, tissue-selective progestins are being developed through a molecular approach to compound selection with human progesterone receptor (hPR) serving as the molecular target. The co-transfection and binding assays are used to test receptor selectivity and cross reactivity with a panel of receptors.
openaire +2 more sources
Action Potential in Charophytes
2007The plant action potential (AP) has been studied for more than half a century. The experimental system was provided mainly by the large charophyte cells, which allowed insertion of early large electrodes, manipulation of cell compartments, and inside and outside media.
openaire +2 more sources
2015
In this chapter we meet the action potential, the fundamental electrical signalling mechanism used by the body. We introduce the cycle of ion movements associated with the generation of an action potential and the role of different ion gates. We then analyse the system of action potential generation in terms of a simple electrical circuit model.
Michael Chappell, Stephen Payne
openaire +1 more source
In this chapter we meet the action potential, the fundamental electrical signalling mechanism used by the body. We introduce the cycle of ion movements associated with the generation of an action potential and the role of different ion gates. We then analyse the system of action potential generation in terms of a simple electrical circuit model.
Michael Chappell, Stephen Payne
openaire +1 more source