Results 171 to 180 of about 762,494 (319)

Activity-dependent ectopic action potentials in regular-spiking neurons of the neocortex. [PDF]

Front Cell Neurosci, 2023
Zhang YZ, Sapantzi S, Lin A, Doelfel SR, Connors BW, Theyel BB.   +5 more
europepmc   +1 more source

The effect of ischemia on the peripheral nerve action potential in man and its relation to somatosensory magnitude coding [PDF]

, 1967
William R. Uttal
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Detection of spinal action potentials with subdural electrodes in freely moving rodents. [PDF]

Sci Rep
Hazelgrove B, Harland B, Lopez S, Asplund M, Cheng LK, Svirskis D, Raos B.   +6 more
europepmc   +1 more source

Reproducibility study of the Fabbri et al. 2017 model of the human sinus node action potential

, 2021
Nima Afshar, Alan Fabbri, Stefano Severi, Alan Garny, David Nickerson   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Annihilation of action potentials induces electrical coupling between neurons. [PDF]

Elife
Schloetter M, Maret GU, Kleineidam CJ.
europepmc   +1 more source

Ionic basis of the different action potential configurations of single guinea‐pig atrial and ventricular myocytes. [PDF]

, 1985
Joseph R. Hume, A. Uehara
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A topological method of generating action potentials and electroencephalography oscillations in a surface network. [PDF]

R Soc Open Sci
Sen S.
europepmc   +1 more source