Results 201 to 210 of about 762,494 (319)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Calmodulin D133H Disrupts Ca_v1.2 and K_v7.1 Regulation to Prolong Cardiac Action Potentials in Long QT Syndrome. [PDF]

Cells
Gupta N, McCormick LF, Richards EMB, Wadmore K, Morris R, Morris VS, Kirilenko P, Fowler ED, Dart C, Helassa N.   +9 more
europepmc   +1 more source

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets. [PDF]

Sci Adv, 2023
Han Y, Yang J, Li Y, Chen Y, Ren H, Ding R, Qian W, Ren K, Xie B, Deng M, Xiao Y, Chu J, Zou P.   +12 more
europepmc   +1 more source

Junctional resistance and action potential delay between embryonic heart cell aggregates. [PDF]

, 1980
David E. Clapham, Alvin Shrier, Remy Dehaan   +2 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The brain-eye connection: More than just action potentials. [PDF]

J Exp Med
Walsh J.
europepmc   +1 more source

Electrically evoked compound action potentials in cochlear implant users with preoperative residual hearing. [PDF]

Front Hum Neurosci, 2023
Liebscher T, Hornung J, Hoppe U.
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Normal locomotion in zebrafish lacking the sodium channel NaV1.4 suggests that the need for muscle action potentials is not universal. [PDF]

PLoS Biol
Akiyama C, Sakata S, Ono F.
europepmc   +1 more source

Optical recording of action potential initiation and propagation in mouse skeletal muscle fibers [PDF]

, 2018
Quinton Banks, Stephen J. P. Pratt, Satish R. Iyer, Richard M. Lovering, Erick O. Hernández‐Ochoa, Martin F. Schneider   +5 more
openalex   +1 more source