Results 81 to 90 of about 14,230,890 (402)

A Mathematical Study of Effects of Alzheimer’s Drug Donepezil Hydrochloride on Neuronal Viscoelasticity and Action Potentials

open access: yesMathematical and Computational Applications
Alzheimer’s disease (AD) is a degenerative disorder characterized by progressive cognitive decline and memory loss. The few contemporary therapies may ease symptoms and/or slow down AD progression but cannot cure the disease.
Corina S. Drapaca
doaj   +1 more source

Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons

open access: yesFrontiers in Molecular Neuroscience, 2022
Fetal and infant brains are rich in maternally derived taurine. We previously demonstrated that taurine action regulates the cation-chloride cotransporter activity and the differentiation and radial migration of pyramidal neuron progenitors in the ...
Yasushi Hosoi   +7 more
doaj   +1 more source

Beta Function Quintessence Cosmological Parameters and Fundamental Constants I: Power and Inverse Power Law Dark Energy Potentials

open access: yes, 2018
This investigation explores using the beta function formalism to calculate analytic solutions for the observable parameters in rolling scalar field cosmologies.
Thompson, Rodger I.
core   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

open access: yesFEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Modeling specific action potentials in the human atria based on a minimal reaction-diffusion model

open access: yes, 2017
We present an effective method to model empirical action potentials of specific patients in the human atria based on the minimal model of Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology.
Lind, Pedro G.   +2 more
core   +2 more sources

Spectral action, Weyl anomaly and the Higgs-Dilaton potential [PDF]

open access: yes, 2011
We show how the bosonic spectral action emerges from the fermionic action by the renormalization group flow in the presence of a dilaton and the Weyl anomaly. The induced action comes out to be basically the Chamseddine-Connes spectral action introduced in the context of noncommutative geometry.
arxiv   +1 more source

Sub-action Prototype Learning for Point-level Weakly-supervised Temporal Action Localization [PDF]

open access: yesarXiv, 2023
Point-level weakly-supervised temporal action localization (PWTAL) aims to localize actions with only a single timestamp annotation for each action instance. Existing methods tend to mine dense pseudo labels to alleviate the label sparsity, but overlook the potential sub-action temporal structures, resulting in inferior performance.
arxiv  

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

The DBI Action, Higher-derivative Supergravity, and Flattening Inflaton Potentials [PDF]

open access: yes, 2016
In string theory compactifications it is common to find an effective Lagrangian for the scalar fields with a non-canonical kinetic term. We study the effective action of the scalar position moduli of Type II D$p$-branes.
Bielleman, Sjoerd   +4 more
core   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

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