Results 101 to 110 of about 8,572,830 (273)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Roof renewal disparities widen the equity gap in residential wildfire protection

Nature Communications
Wildfires are having disproportionate impacts on U.S. households. Notably, in California, over half of wildfire-destroyed homes (54%) are in low-income areas.
Sebastian Reining, Moritz Wussow, Chad Zanocco, Dirk Neumann   +3 more
doaj   +1 more source

Using Systems Engineering to Translate Research into Action [PDF]

No abstract ...
McGuire, Kerry, Urbina, Michelle
core   +1 more source

Videomaking. Action-Research Experimentations in Highly Diverse Communities [PDF]

, 2017
The clear, steady, peaceful water of the Caribbean sea, customary depicted in old postcards or in touristic advertises, doesn’t account properly of the turbid tides and waves which are shaking the human and physical landscape of the Lesser Antilles ...
giovanni attili
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cognitive, Mental and Vascular Health Among People Living with HIV in the Country of Georgia

Cerebral Circulation - Cognition and Behavior
Introduction: In Eastern Europe and Central Asia, the relevant literature on vascular contributors to cognitive impairments and mental health disorders is scarce.
Esma Imerlishvili, Deborah Gustafson, Davit Baliashvili, Ana Karaulashvili, Tamar Zurashvili, Mamuka Djibuti   +5 more
doaj   +1 more source

Collaborative action research in the chilean EFL classroom [PDF]

, 2017
Tesis (Profesor de Inglés, Licenciado en Educación)Este estudio discute los resultados obtenidos en una investigación cualitativa que involucra a un docente en formación como profesor-investigador en una Investigación-Acción, en un colegio de Santiago de
Espina, Fernanda, Lagos, Jaime, Medina, Andrea, Pilquinao, Samuel   +3 more
core  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The experience of UK patients with bladder cancer during the second wave of the COVID‐19 pandemic

BJUI Compass, 2022
Beth Russell, Sarah Spencer‐Bowdage, Jeannie Rigby, Jackie O'Kelly, Phil Kelly, Mark Page, Caroline Raw, Paula Allchorne, Peter Harper, Jeremy Crew, Roger Kockelbergh, Allen Knight, Mieke Van Hemelrijck, Richard T. Bryan   +13 more
doaj   +1 more source