Results 111 to 120 of about 8,572,830 (273)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Exploring the complexities of slum vulnerability in Haryana, India: a qualitative research journey into economic, social, physical, and health dimensions

International Journal of Qualitative Studies on Health & Well-Being
Purpose The study explores the conditions contributing to slum dweller’s vulnerability to poor health and examines interplay between economic, physical/infrastructural, and social factors affecting health status to inform policy and programme.
Manmeet Kaur, Abhishek Sharma, PP Vijin, Rupinder Kaur, Rajbir Kaur, G. Anupama, Prabhjot Singh, V.K Bansal, Nidhi Sharma, Mona Sahni, Jyoti Gupta, Pvm Lakshmi, Rajesh Kumar   +12 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Tree-to-Me: Standards-Driven Traceability for Farm-Level Visibility

Agronomy
Traditional horticultural information systems lack fine-grained, transparent on-farm event traceability, often providing only high-level post-harvest summaries.
Ya Cho, Arbind Agrahari Baniya, Kieran Murphy   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Action research

Communications of the ACM, 1999
Avison, D., Lau, F., Myers, M., Nielsen, Peter Axel; id_orcid 0000-0002-0282-7445   +3 more
openaire   +2 more sources

Student’s classroom participation in English language teaching: The case of Gozamen General Secondary School in Grade 10-A [PDF]

, 2014
Student’s classroom participation in English language teaching: The case of Gozamen General Secondary School in Grade 10-A Author / Authors : Atalay Mesfin Aneteneh Page no. 204-217 Discipline : Education
Aneteneh, Atalay Mesfin
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Undisciplined Nature of Ecological Design [PDF]

, 2009
The author evaluates the results of a participatory action research that takes place amidst a private design school located in Rio de Janeiro, Brazil.
Barbosa, Joao Carlos Lutz
core