Results 161 to 170 of about 8,600,421 (324)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organizational Learning and Action Research

, 2012
Roberto Albano, Tommaso Fabbri, Ylenia Curzi   +2 more
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Using action research for workforce development and planning in integrated care

, 2017
Beverley Joy Akehurst
openalex   +1 more source

Lean thinking in the food supply chain: an action case research [PDF]

The purpose of the study is to examine the adoption of lean tools in food supply chains as well as to understand how small and medium companies (SMEs) can implement lean tools in order to develop a lean action plan designed for SMEs.
Vlachos, Ilias
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Social organization for improved system management and sustainable irrigated agriculture in small dams: an action research program. Yearly progress report, 1 April 1997 to 31st March 1998 on DFID-Funded Action Research Project [PDF]

, 1998
M. A. Cheema, D. J. Bandaragoda
openalex  

Improving Innovative Capabilities of Trucking Company: Action Research Approach [PDF]

, 2023
Kyatmaja Lookman, I Nyoman Pujawan, Reny Nadlifatin   +2 more
openalex   +1 more source

Collaborative action research for the governance of climate adaptation - foundations, conditions and pitfalls [PDF]

This position paper serves as an introductory guide to designing and facilitating an action research process with stakeholders in the context of climate adaptation.
Buuren, M., van, Eshuis, J., Huntjens, P.M.J.M., Termeer, C.J.A.M.   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source