Results 91 to 100 of about 153,708 (298)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Frontiers in Immunology, 2017 Alpha7 nicotinic acetylcholine receptor (α7nAChR) has been reported to alleviate neuroinflammation. Here, we aimed to determine the role of autophagy in α7nAChR-mediated inhibition of neuroinflammation and its underlying mechanism.
Bo-Zong Shao +8 more
doaj +1 more source
Extreme Ultraviolet Emission in the Fornax Cluster of Galaxies [PDF]
, 2001 We present studies of the Extreme Ultraviolet (EUV) emission in the Fornax cluster of galaxies; a relatively nearby well-studied cluster with X-ray emitting cluster gas and a very large radio source.
Eric Korpela +4 more
core +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Journal of Materials Research and TechnologyDue to its high thermal expansion coefficient and high thermal conductivity, welding of copper and copper alloys is considered difficult and demanding.
Matija Bušić +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Neutron Flux Self-shielding in Activation Analysis
RADIOISOTOPES, 1980 Some effects of self-shielding of neutron flux in neutron activation analysis have been investigated. Induced specific activities in dilute samples were compared with those in solid elements irradiated under the same conditions. Two factors affecting the neutron flux were investigated: thermal neutron self-shielding and epithermal neutron self ...
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Flux-Flux And Activity-Rotation Relationships In Early-M Dwarfs
, 2016 While most of the planets discovered so far have been found orbiting around solar-type stars, low-mass stars have been recognised as a "shortcut" to glance into an exo-life laboratory. Currently, stellar activity is one of the most limiting factors for achieving the precision required to detect Earth-twins via the radial velocity method.
Maldonado, J., Scandariato, G.
openaire +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source