Results 1 to 10 of about 42,282 (208)

Impaired Autophagic Flux in Adipose Tissue Aggravates Pancreatic Injury in Obesity‐Related Severe Acute Pancreatitis [PDF]

Immunity, Inflammation and Disease
Background Adipose tissue (AT) playing a crucial role in obesity‐related pancreatitis. This study investigated the impact of autophagy in AT on pancreatic injury during obesity‐related severe acute pancreatitis (SAP).
Li‐Ping Sheng, Guo‐Chen Shang, Chao‐Qun Han, Xin Ling, Xian‐Wen Guo, Rong Lin, Zhen Ding   +6 more
doaj   +2 more sources

The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach

Cells, 2018
Autophagy failure is implicated in age-related human disease. A decrease in the rate of protein degradation through the entire autophagy pathway, i.e., autophagic flux, has been associated with the onset of cellular proteotoxity and cell death.
André du Toit, Sholto De Wet, Jan-Hendrik S. Hofmeyr, Kristian K. Müller-Nedebock, Ben Loos   +4 more
doaj   +3 more sources

Ingenane Diterpenoids from Euphorbia peplus: Structure Elucidation and Autophagic Flux Activation Activity [PDF]

Molecules
Autophagy dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD), and enhancing autophagic flux has been proposed as a potential strategy for addressing neurodegenerative diseases.
Jiajia Wan, Qingyun Lu, Zifei Xu, Xiaojiang Hao, Rongcan Luo, Yingtong Di   +5 more
doaj   +2 more sources

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux

Cell Reports, 2018
Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim, Seoyoung Park, Jung Hoon Lee, Ji Young Mun, Won Hoon Choi, Yejin Yun, Jeeyoung Lee, Ji Hyeon Kim, Min-Ji Kang, Min Jae Lee   +9 more
doaj   +3 more sources

Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication

Cell Reports, 2018
Summary: Picornaviruses have evolved to hijack host cellular machinery, including the autophagic pathway. However, the mechanisms remain largely unclear.
Yasir Mohamud, Junyan Shi, Junyan Qu, Tak Poon, Yuan Chao Xue, Haoyu Deng, Jingchun Zhang, Honglin Luo   +7 more
doaj   +3 more sources

Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC

Frontiers in Oncology
IntroductionSmall cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance.
Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu, Zhe Liu, Zhe Liu   +6 more
doaj   +3 more sources

Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function

The EMBO Journal
Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due to altered mitophagy and protein quality control. However, whether additional mechanisms are involved in the development of mitochondrial dysfunction and heart ...
Quanjiang Zhang, Zhonggang Li, Qiuxia Li, Samuel AJ Trammell, Mark S Schmidt, Karla Maria Pires, Jinjin Cai, Yuan Zhang, Helena Kenny, Sihem Boudina, Charles Brenner, E Dale Abel   +11 more
doaj   +2 more sources

Development of small fluorescent probes for the analysis of autophagy kinetics

iScience, 2023
Summary: Autophagy is a dynamic process that degrades subcellular constituents, and its activity is measured by autophagic flux. The tandem proteins RFP-GFP-LC3 and GFP-LC3-RFP-LC3ΔG, which enable the visualization of autophagic vacuoles of different ...
Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu   +9 more
doaj   +1 more source

A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

eLife, 2022
Monitoring autophagic flux is necessary for most autophagy studies. The autophagic flux assays currently available for mammalian cells are generally complicated and do not yield highly quantitative results.
Willa Wen-You Yim, Hayashi Yamamoto, Noboru Mizushima   +2 more
doaj   +1 more source

Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance

Cell Death and Disease, 2021
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still ...
Aniketh Bishnu, Pratham Phadte, Ajit Dhadve, Asmita Sakpal, Bharat Rekhi, Pritha Ray   +5 more
doaj   +1 more source