Results 1 to 10 of about 57,206 (302)

Impaired Autophagic Flux in Adipose Tissue Aggravates Pancreatic Injury in Obesity‐Related Severe Acute Pancreatitis [PDF]

Immunity, Inflammation and Disease
Background Adipose tissue (AT) playing a crucial role in obesity‐related pancreatitis. This study investigated the impact of autophagy in AT on pancreatic injury during obesity‐related severe acute pancreatitis (SAP).
Li‐Ping Sheng, Guo‐Chen Shang, Chao‐Qun Han, Xin Ling, Xian‐Wen Guo, Rong Lin, Zhen Ding   +6 more
doaj   +2 more sources

Autophagic flux modulates tumor heterogeneity and lineage plasticity in SCLC [PDF]

Frontiers in Oncology
IntroductionSmall cell lung cancer (SCLC) is characterized by significant heterogeneity and plasticity, contributing to its aggressive progression and therapy resistance.
Yujie Hao, Mingchen Li, Wenxu Liu, Zhenyi Ma, Zhe Liu, Zhe Liu, Zhe Liu   +6 more
doaj   +2 more sources

Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer [PDF]

Cancer Cell International
Background Breast cancer remains the most prevalent malignancy in women. Chemotherapy is the primary systemic treatment modality, and the effectiveness of treatment is often hampered by chemoresistance.
Yinjiao Fei, Xueqin Yan, Mingxing Liang, Shu Zhou, Di Xu, Lei Li, Weilin Xu, Yuxin Song, Zhen Zhu, Jian Zhang   +9 more
doaj   +2 more sources

Mechanism of mTOR/RILP-regulated autophagic flux in increased susceptibility to myocardial ischemia-reperfusion in diabetic mice [PDF]

Frontiers in Pharmacology
BackgroundThe increased myocardial vulnerability that occurs in diabetic patients following an ischemia-reperfusion injury (I/RI) represents a significant perioperative safety risk.
Jiyao Zhao, Wei Shi, Yan Zheng, Junjie Wang, Muzhao Yuan, Yultuz Anwar, Yuxuan He, Haiping Ma, Jianjiang Wu   +8 more
doaj   +2 more sources

Development of small fluorescent probes for the analysis of autophagy kinetics

iScience, 2023
Summary: Autophagy is a dynamic process that degrades subcellular constituents, and its activity is measured by autophagic flux. The tandem proteins RFP-GFP-LC3 and GFP-LC3-RFP-LC3ΔG, which enable the visualization of autophagic vacuoles of different ...
Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu   +9 more
doaj   +1 more source

A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag

eLife, 2022
Monitoring autophagic flux is necessary for most autophagy studies. The autophagic flux assays currently available for mammalian cells are generally complicated and do not yield highly quantitative results.
Willa Wen-You Yim, Hayashi Yamamoto, Noboru Mizushima   +2 more
doaj   +1 more source

Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance

Cell Death and Disease, 2021
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical evidences of strong association between enhanced autophagic flux with acquired chemoresistance, it is still ...
Aniketh Bishnu, Pratham Phadte, Ajit Dhadve, Asmita Sakpal, Bharat Rekhi, Pritha Ray   +5 more
doaj   +1 more source

PPARα Inhibits Astrocyte Inflammation Activation by Restoring Autophagic Flux after Transient Brain Ischemia

Biomedicines, 2023
Astrocyte inflammation activation is an important cause that hinders the recovery of motor function after cerebral ischemia. However, its molecular mechanism has not yet been clearly clarified.
Doudou Luo, Wenxuan Ye, Ling Chen, Xiaoqian Yuan, Yali Zhang, Caixia Chen, Xin Jin, Yu Zhou   +7 more
doaj   +1 more source

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. [PDF]

, 2015
Serous Ovarian Cancers (SOC) are frequently resistant to programmed cell death. However, here we describe that these programmed death-resistant cells are nonetheless sensitive to agents that modulate autophagy.
Bartakova, Alena, Davis, Mitzie-Ann, Delaney, Joe R, Haft, Carley, Lu, Dan, McCabe, Katelyn E, Patel, Chandni, Schlaepfer, David D, Stupack, Dwayne G, Tancioni, Isabelle, von Schalscha, Tami   +10 more
core   +11 more sources

Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux. [PDF]

PLoS ONE, 2016
Conessine, a steroidal alkaloid isolated from Holarrhena floribunda, has anti-malarial activity and interacts with the histamine H3 receptor. However, the cellular effects of conessine are poorly understood.
Hyunju Kim, Kang Il Lee, Minsu Jang, Sim Namkoong, Rackhyun Park, Hyunwoo Ju, Inho Choi, Won Keun Oh, Junsoo Park   +8 more
doaj   +1 more source