Results 41 to 50 of about 57,206 (302)
Three consecutive cytosolic glycolysis enzymes modulate autophagic flux
Plant Physiology, 2023 Abstract Autophagy serves as an important recycling route for the growth and survival of eukaryotic organisms in nutrient-deficient conditions. Since starvation induces massive changes in the metabolic flux that are coordinated by key metabolic enzymes, specific processing steps of autophagy may be linked with metabolic flux-monitoring ...
Du-Hwa Lee +6 more
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Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux [PDF]
International Journal of Molecular Sciences, 2021 Diosmin, a natural flavone glycoside acquired through dehydrogenation of the analogous flavanone glycoside hesperidin, is plentiful in many citrus fruits. Glioblastoma multiforme (GBM) is the most malignant primary brain tumor; the average survival time of GBM patients is less than 18 months after standard treatment. The present study demonstrated that
Yung-Lung Chang +6 more
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Using cultured canine cardiac slices to model the autophagic flux with doxorubicin.
PLoS ONE, 2023 Chemotherapy-induced impairment of autophagy is implicated in cardiac toxicity induced by anti-cancer drugs. Imperfect translation from rodent models and lack of in vitro models of toxicity has limited investigation of autophagic flux dysregulation ...
Asma Boukhalfa +11 more
doaj +1 more source
Regulation of Autophagic Flux by the 20S Proteasome [PDF]
Cell Chemical Biology, 2019 The proteolytic arm of the protein homeostasis network is maintained by both the ubiquitin-proteasome system (UPS) and autophagy. A well-balanced crosstalk between the two catabolic pathways ensures energy-efficient maintenance of cellular function. Our current understanding of the crosstalk between the UPS and autophagy is centered around substrate ...
Evert Njomen, Jetze J. Tepe
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Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source
Rapamycin induces autophagic flux in neurons [PDF]
Proceedings of the National Academy of Sciences, 2010 Autophagy is a bulk degradation process initiated when cells engulf cytoplasm (including organelles) within double-membraned vesicles, called autophagosomes, that ultimately fuse to lysosomes, where their contents are degraded. Despite extensive data showing that mammalian target of rapamycin (mTOR) kinase inhibition by rapamycin induces autophagy in ...
David C. Rubinsztein, Ralph A. Nixon
openaire +1 more source
Neurobiology of Disease, 2014 Niemann–Pick disease type C (NPC) is a fatal, progressive neurovisceral disorder. Several studies report that the autophagic flux is disturbed in NPC1-deficient (NPC1−/−) cells. Since it has been suggested that the autophagic defect may contribute to the
Volker Meske +3 more
doaj +1 more source
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy. [PDF]
, 2017 Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes involved in excitation-contraction coupling for power of contraction. Little is known about how T-tubules maintain highly organized structures and contacts throughout
Fujita, Naonobu +10 more
core +2 more sources
PLoS ONE, 2014 Epigallocatechin gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the impairment in learning and memory. Autophagy is a cellular process that protects neurons from stressful conditions.
Hong-Feng Gu +7 more
doaj +1 more source
Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy [PDF]
, 2015 Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates ...
Aggarwal, Tanya +15 more
core +2 more sources