Results 51 to 60 of about 57,206 (302)
Lipid storage and autophagy in melanoma cancer cells [PDF]
, 2017 Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina +9 more
core +2 more sources
The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]
, 2020 Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro +12 more
core +1 more source
Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy
International Journal of Molecular Sciences, 2023 Autophagy has stabilizing functions for cardiomyocytes. Recent studies indicate that an impairment in the autophagy pathway can seriously affect morphology and function, potentially leading to heart failure. However, the role and the underlying mechanism of the endosomal sorting complex required for transport (ESCRT) family protein, in particular the ...
Huang, Xiaozhi +4 more
openaire +2 more sources
Frontiers in Oncology, 2019 Although the cancer/testis antigen CAGE has been implicated in tumorigenesis, the molecular mechanisms of CAGE-promoted tumorigenesis remain largely unknown.
Minjeong Yeon +5 more
doaj +1 more source
The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux [PDF]
Scientific Reports, 2019 AbstractAntidepressants are commonly prescribed psychotropic substances for the symptomatic treatment of mood disorders. Their primary mechanism of action is the modulation of neurotransmission and the consequent accumulation of monoamines, such as serotonin and noradrenaline.
Federica Cavaliere +10 more
openaire +3 more sources
Frontiers in Pharmacology, 2021 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory damage and cognitive dysfunction. Studies have shown that defective autophagic flux is associated with neuronal dysfunction.
Zhenwan Li +3 more
doaj +1 more source
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection [PDF]
, 2016 open12openJanda, Elzbieta; Lascala, Antonella; Carresi, Cristina; Parafati, Maddalena; Aprigliano, Serafina; Russo, Vanessa; Savoia, Claudia; Ziviani, Elena; Musolino, VINCENZO MARIA; Morani, Federica; Isidoro, Ciro; Mollace, VincenzoJanda, Elzbieta ...
core +1 more source
Rab7b modulates autophagic flux by interacting with Atg4B [PDF]
EMBO reports, 2017 Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. The autophagic pathway maintains basal cellular homeostasis and helps cells adapt during stress; thus, defects in autophagy can cause ...
Ingrid Kjos +9 more
openaire +4 more sources
Acta Biochimica et Biophysica Sinica, 2022 Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury.
Lv Ying +8 more
doaj +1 more source
Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion [PDF]
Antioxidants & Redox Signaling, 2011 Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3.
Nirmala, Hariharan +2 more
openaire +2 more sources