Results 31 to 40 of about 57,206 (302)

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]

, 2018
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz, Gasca Bellido, Jessica María, Japón Rodríguez, Miguel Ángel, Jiménez Guerrero, Rocío, Medina, Rafael, Pérez Valderrama, Begoña, Romero Portillo, Francisco, Tortolero García, María Dolores   +7 more
core   +1 more source

Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates [PDF]

Autophagy, 2015
Although numerous techniques have been developed to monitor autophagy and to probe its cellular functions, these methods cannot evaluate in sufficient detail the autophagy process, and suffer limitations from complex experimental setups and/or systematic errors.
Maulucci, Giuseppe, Chiarpotto, Michela, Papi, Massimiliano, Samengo, Daniela Maria, Pani, Giovambattista, De Spirito, Marco   +5 more
openaire   +2 more sources

Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin [PDF]

, 2015
Autophagy is a lysosomal catabolic route for protein aggregates and damaged organelles which in different stress conditions, such as starvation, generally improves cell survival.
Catizone, Angiolina, De Vito, S, Fabrizi, C, Fornai, F, Fumagalli, Lorenzo, Lenzi, P, Pompili, Elena, Ricci, G, Somma, Francesca   +8 more
core   +2 more sources

Why should autophagic flux be assessed? [PDF]

Acta Pharmacologica Sinica, 2013
As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders.
Xiao-jie, Zhang, Sheng, Chen, Kai-xing, Huang, Wei-dong, Le   +3 more
openaire   +2 more sources

DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose [PDF]

, 2015
Macroautophagy is a membrane-trafficking process that delivers cytoplasmic constituents to lysosomes for degradation. The process operates under basal conditions as a mechanism to turnover damaged or misfolded proteins and organelles. As a result, it has
A Kuma, A Stolz, AD Baudot, AM Choi, B Levine, B Levine, B Ravikumar, D Crighton, D Crighton, D Crighton, D Strachan, DJ Klionsky, DW Hailey, EL Axe, EL Eskelinen, F Beaumatin, F Corpet, H Harlin, I Kissova, J O'Prey, J O'Prey, J S Long, J Skommer, JJ Lemasters, JJ Lum, JS Long, K M Ryan, KM Ryan, KM Ryan, L Cong, L Y Lao, LA Bell, LY Mah, M Mrschtik, M O'Prey, MT Rosenfeldt, MT Rosenfeldt, N Mizushima, N Mizushima, P Boya, S Hehlgans, S Wilkinson, SA Tooze, SW Tait, Y Kabeya, Y Kamada, Y Ohsumi, Z Xie   +47 more
core   +2 more sources

The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]

, 2015
This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, Filardi, M, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TORRISI, Maria Rosaria   +7 more
core   +1 more source

MTX-PEG-modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple-negative breast cancer

Breast Cancer Research, 2023
The chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised off-target.
Zhiwen Cao, Rui Liu, Yang Li, Xinyi Luo, Zhenglai Hua, Xiangpeng Wang, Zeyu Xue, Zhengjia Zhang, Cheng Lu, Aiping Lu, Yuanyan Liu   +10 more
doaj   +1 more source

Stress while lacking of control induces ventral hippocampal autophagic flux hyperactivity and a depression-like behavior

Biomedical Journal, 2022
Background: Stressed animals may perform depression-like behavior insomuch as stress-provoking blood–brain barrier (BBB) disruption, central immune activation, and autophagic flux changes.
Yi-Han Liao, Ya-Hsuan Chan, Hao Chen, Anna E. Yu, Li-Han Sun, Wei-Jen Yao, Lung Yu   +6 more
doaj   +1 more source

Flow Cytometric Analyses of Autophagic Activity using LC3-GFP fluorescence

Bio-Protocol, 2014
Flow cytometry allows very sensitive and reliable high-throughput analysis of autophagic flux. This methodology permits to screen cells in flow and capture multi-component images.
Metodi Stankov, Diana Panayotova-Dimitrova, Martin Leverkus, Georg Behrens   +3 more
doaj   +1 more source

Lipid droplets and lipotoxicity during autophagy. [PDF]

, 2017
Lipid droplets (LDs) are neutral lipid storage organelles that provide a rapidly accessible source of fatty acids (FAs) for energy during periods of nutrient deprivation.
Nguyen, Truc, Olzmann, James
core   +2 more sources