Results 21 to 30 of about 42,282 (208)

Stress while lacking of control induces ventral hippocampal autophagic flux hyperactivity and a depression-like behavior

Biomedical Journal, 2022
Background: Stressed animals may perform depression-like behavior insomuch as stress-provoking blood–brain barrier (BBB) disruption, central immune activation, and autophagic flux changes.
Yi-Han Liao, Ya-Hsuan Chan, Hao Chen, Anna E. Yu, Li-Han Sun, Wei-Jen Yao, Lung Yu   +6 more
doaj   +1 more source

MTX-PEG-modified CG/DMMA polymeric micelles for targeted delivery of doxorubicin to induce synergistic autophagic death against triple-negative breast cancer

Breast Cancer Research, 2023
The chemotherapy of triple-negative breast cancer based on doxorubicin (DOX) regimens suffers from great challenges on toxicity and autophagy raised off-target.
Zhiwen Cao, Rui Liu, Yang Li, Xinyi Luo, Zhenglai Hua, Xiangpeng Wang, Zeyu Xue, Zhengjia Zhang, Cheng Lu, Aiping Lu, Yuanyan Liu   +10 more
doaj   +1 more source

Using cultured canine cardiac slices to model the autophagic flux with doxorubicin.

PLoS ONE, 2023
Chemotherapy-induced impairment of autophagy is implicated in cardiac toxicity induced by anti-cancer drugs. Imperfect translation from rodent models and lack of in vitro models of toxicity has limited investigation of autophagic flux dysregulation ...
Asma Boukhalfa, Sally R Robinson, Dawn M Meola, Nicholas A Robinson, Lauren A Ling, Joey N LaMastro, Jenica N Upshaw, Lakshmi Pulakat, Iris Z Jaffe, Cheryl A London, Howard H Chen, Vicky K Yang   +11 more
doaj   +1 more source

Epigallocatechin-3-gallate attenuates impairment of learning and memory in chronic unpredictable mild stress-treated rats by restoring hippocampal autophagic flux.

PLoS ONE, 2014
Epigallocatechin gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the impairment in learning and memory. Autophagy is a cellular process that protects neurons from stressful conditions.
Hong-Feng Gu, Ya-Xiong Nie, Qiao-Zhen Tong, Ya-Ling Tang, Yang Zeng, Kai-Quan Jing, Xi-Long Zheng, Duan-Fang Liao   +7 more
doaj   +1 more source

The autophagic defect in Niemann–Pick disease type C neurons differs from somatic cells and reduces neuronal viability

Neurobiology of Disease, 2014
Niemann–Pick disease type C (NPC) is a fatal, progressive neurovisceral disorder. Several studies report that the autophagic flux is disturbed in NPC1-deficient (NPC1−/−) cells. Since it has been suggested that the autophagic defect may contribute to the
Volker Meske, Jennifer Erz, Timm Priesnitz, Thomas-Georg Ohm   +3 more
doaj   +1 more source

CAGE-miR-140-5p-Wnt1 Axis Regulates Autophagic Flux, Tumorigenic Potential of Mouse Colon Cancer Cells and Cellular Interactions Mediated by Exosomes

Frontiers in Oncology, 2019
Although the cancer/testis antigen CAGE has been implicated in tumorigenesis, the molecular mechanisms of CAGE-promoted tumorigenesis remain largely unknown.
Minjeong Yeon, Seungheon Lee, Joo-Eun Lee, Hyun Suk Jung, Youngmi Kim, Dooil Jeoung   +5 more
doaj   +1 more source

β-Asarone Attenuates Aβ-Induced Neuronal Damage in PC12 Cells Overexpressing APPswe by Restoring Autophagic Flux

Frontiers in Pharmacology, 2021
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory damage and cognitive dysfunction. Studies have shown that defective autophagic flux is associated with neuronal dysfunction.
Zhenwan Li, Jin Ma, Zhongsheng Kuang, Yong Jiang   +3 more
doaj   +1 more source

A fluorescent reporter for rapid assessment of autophagic flux reveals unique autophagy signatures during C. elegans post-embryonic development and identifies compounds that modulate autophagy

Autophagy Reports
Autophagy is important for many physiological processes; and disordered autophagy can contribute to the pathogenesis of a broad range of systemic disorders. C.
Zachary D. Dawson, Hemalatha Sundaramoorthi, Suk Regmi, Bo Zhang, Stephanie Morrison, Sara M. Fielder, Jessie R. Zhang, Hieu Hoang, David H. Perlmutter, Cliff J. Luke, Gary A. Silverman, Stephen C. Pak   +11 more
doaj   +1 more source

ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells

Acta Biochimica et Biophysica Sinica, 2022
Lipotoxicity has been shown to induce the loss of functional β-cell mass and lead to type 2 diabetes, but the mechanism remains unknown. In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury.
Lv Ying, Xiao Sijie, Ouyang Shuhui, Peng Zhengliang, Wu Li, Tang Ziqing, Zhang Weizheng, Cao Renxian, Yang Jing   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source