Results 21 to 30 of about 57,206 (302)
Frontiers in Cell and Developmental Biology, 2021 Cancer-associated gene (CAGE), a cancer/testis antigen, has been known to promote anticancer drug resistance. Since the underlying mechanisms of CAGE-promoted anticancer drug resistance are poorly understood, we established Anticancer drug-resistant ...
Minjeong Yeon +8 more
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Miz1 is required to maintain autophagic flux [PDF]
Nature Communications, 2013 Miz1 is a zinc finger protein that regulates the expression of cell cycle inhibitors as part of a complex with Myc. Cell cycle-independent functions of Miz1 are poorly understood. Here we use a Nestin-Cre transgene to delete an essential domain of Miz1 in the central nervous system (Miz1(ΔPOZNes)).
Elmar, Wolf +10 more
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Determination of the autophagic flux in murine and human peripheral blood mononuclear cells
Frontiers in Cell and Developmental Biology, 2023 The autophagy lysosomal system (ALS) is crucial for cellular homeostasis, contributing to maintain whole body health and alterations are associated with diseases like cancer or cardiovascular diseases.
Sophia Walter +14 more
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MTOR regulates autophagic flux in the glomerulus [PDF]
Autophagy, 2012 Sirolimus (rapamycin), an inhibitor of the mechanistic target of rapamycin (MTOR), was originally proposed as an immunosuppressant to prevent rejection of solid organ transplants. There were expectations that MTOR inhibitors would replace nephrotoxic calcineurin inhibitors (CNIs). Despite its potential advantages, evidence that sirolimus causes de novo
Davide P, Cinà +7 more
openaire +2 more sources
S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux
Cells, 2021 Autophagy is a specific macromolecule and organelle degradation process. The target macromolecule or organelle is first enclosed in an autophagosome, and then delivered along acetylated microtubules to the lysosome.
Aleksandra Hać +2 more
doaj +1 more source
Small fluorescent molecules for monitoring autophagic flux [PDF]
FEBS Letters, 2018 We have developed two types of fluorescent probes, DALGreen and DAPGreen, for monitoring autophagy, that exhibit fluorescence upon being incorporated into autophagosomes. DALGreen enhances its fluorescence at acidic pH, which is favorable for monitoring late‐phase autophagy, whereas DAPGreen remains fluorescent with almost constant brightness during ...
Iwashita, Hidefumi +8 more
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Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
Cells, 2021 Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understood ...
Katharina Körholz +10 more
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Autophagic flux is required for the synthesis of triacylglycerols and ribosomal protein turnover in Chlamydomonas [PDF]
, 2018 Autophagy is an intracellular catabolic process that allows cells to recycle unneeded or damaged material to maintain cellular homeostasis. This highly dynamic process is characterized by the formation of double-membrane vesicles called autophagosomes ...
Couso Liáñez, Inmaculada Concepción +4 more
core +1 more source
Using enhanced-mitophagy to measure autophagic flux [PDF]
Methods, 2015 Macroautophagy (hereafter termed autophagy) is a cellular membrane-trafficking process that functions to deliver cytoplasmic constituents to lysosomes for degradation. Autophagy operates at basal levels to turn over damaged and misfolded proteins and it is the only process for the turnover of organelles.
Baudot, Alice +4 more
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Cell Communication and Signaling, 2022 Background Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradation of damaged organelle.
Yunash Maharjan +6 more
doaj +1 more source