Results 11 to 20 of about 42,282 (208)
TRPML1 agonist ML-SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux. [PDF]
FEBS Open BioTGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Yao J +10 more
europepmc +2 more sources
Biomedicines, 2023 Astrocyte inflammation activation is an important cause that hinders the recovery of motor function after cerebral ischemia. However, its molecular mechanism has not yet been clearly clarified.
Doudou Luo +7 more
doaj +1 more source
Conessine Interferes with Oxidative Stress-Induced C2C12 Myoblast Cell Death through Inhibition of Autophagic Flux. [PDF]
PLoS ONE, 2016 Conessine, a steroidal alkaloid isolated from Holarrhena floribunda, has anti-malarial activity and interacts with the histamine H3 receptor. However, the cellular effects of conessine are poorly understood.
Hyunju Kim +8 more
doaj +1 more source
Journal of Advanced Research, 2021 Introduction: We have previously demonstrated the antagonistic role of hydrogen sulfide (H2S) in the cognitive dysfunction of streptozotocin (STZ)-induced diabetic rats.
Xuan Kang +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Cancer-associated gene (CAGE), a cancer/testis antigen, has been known to promote anticancer drug resistance. Since the underlying mechanisms of CAGE-promoted anticancer drug resistance are poorly understood, we established Anticancer drug-resistant ...
Minjeong Yeon +8 more
doaj +1 more source
Determination of the autophagic flux in murine and human peripheral blood mononuclear cells
Frontiers in Cell and Developmental Biology, 2023 The autophagy lysosomal system (ALS) is crucial for cellular homeostasis, contributing to maintain whole body health and alterations are associated with diseases like cancer or cardiovascular diseases.
Sophia Walter +14 more
doaj +1 more source
S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux
Cells, 2021 Autophagy is a specific macromolecule and organelle degradation process. The target macromolecule or organelle is first enclosed in an autophagosome, and then delivered along acetylated microtubules to the lysosome.
Aleksandra Hać +2 more
doaj +1 more source
Cell Communication and Signaling, 2022 Background Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradation of damaged organelle.
Yunash Maharjan +6 more
doaj +1 more source
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
Cells, 2021 Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understood ...
Katharina Körholz +10 more
doaj +1 more source
Flow Cytometric Analyses of Autophagic Activity using LC3-GFP fluorescence
Bio-Protocol, 2014 Flow cytometry allows very sensitive and reliable high-throughput analysis of autophagic flux. This methodology permits to screen cells in flow and capture multi-component images.
Metodi Stankov +3 more
doaj +1 more source