Results 11 to 20 of about 57,206 (302)
Basal ryanodine receptor activity suppresses autophagic flux [PDF]
Biochemical Pharmacology, 2017 The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway.
Bannai, Hiroko +9 more
core +5 more sources
Journal of Advanced Research, 2021 Introduction: We have previously demonstrated the antagonistic role of hydrogen sulfide (H2S) in the cognitive dysfunction of streptozotocin (STZ)-induced diabetic rats.
Xuan Kang +8 more
doaj +3 more sources
Interleukin-4 affects microglial autophagic flux
Neural Regeneration Research, 2019 Interleukin-4 plays an important protective role in Alzheimer’s disease by regulating microglial phenotype, phagocytosis of amyloid-β, and secretion of anti-inflammatory and neurotrophic cytokines.
Run-Hong Tang, Rui-Qun Qi, Hua-Yan Liu
doaj +3 more sources
Atg4b-dependent autophagic flux alleviates Huntington's disease progression. [PDF]
PLoS ONE, 2013 The accumulation of aggregated mutant huntingtin (mHtt) inclusion bodies is involved in Huntigton's disease (HD) progression. Medium sized-spiny neurons (MSNs) in the corpus striatum are highly vulnerable to mHtt aggregate accumulation and degeneration ...
Catia C Proenca +11 more
doaj +4 more sources
Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux
Cell Reports, 2018 Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim +9 more
doaj +3 more sources
Cell Reports, 2018 Summary: Picornaviruses have evolved to hijack host cellular machinery, including the autophagic pathway. However, the mechanisms remain largely unclear.
Yasir Mohamud +7 more
doaj +3 more sources
A method to measure cardiac autophagic flux in vivo [PDF]
Autophagy, 2008 Autophagy, a highly conserved cellular mechanism wherein various cellular components are broken down and recycled through lysosomes, has been implicated in the development of heart failure. However, tools to measure autophagic flux in vivo have been limited.
Eri, Iwai-Kanai +6 more
openaire +4 more sources
Surgical procedures suppress autophagic flux in the kidney [PDF]
Cell Death & Disease, 2021 AbstractMany surgical models are used to study kidney and other diseases in mice, yet the effects of the surgical procedure itself on the kidney and other tissues have not been elucidated. In the present study, we found that both sham surgery and unilateral nephrectomy (UNX), which is used as a model of renal compensatory hypertrophy, in mice resulted ...
Carolyn N. Brown +11 more
openaire +3 more sources
Regulation of autophagic flux by CHIP [PDF]
Neuroscience Bulletin, 2015 Autophagy is a major degradation system which processes substrates through the steps of autophagosome formation, autophagosome-lysosome fusion, and substrate degradation. Aberrant autophagic flux is present in many pathological conditions including neurodegeneration and tumors. CHIP/STUB1, an E3 ligase, plays an important role in neurodegeneration.
Dongkai, Guo +6 more
openaire +2 more sources
Endothelial autophagic flux hampers atherosclerotic lesion development [PDF]
Autophagy, 2018 Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogeneous and atherosclerotic plaques develop preferentially in areas where shear is low or disturbed. Here we review our recent study
Kheloufi, Marouane +19 more
openaire +4 more sources