Results 21 to 30 of about 153,708 (298)

RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts

Cell Death and Disease, 2022
Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear.
Shigang Qiao, Lei Hong, Yongming Zhu, Jun Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, Huiling Zhang   +9 more
doaj   +1 more source

Melatonin Restores Autophagic Flux by Activating the Sirt3/TFEB Signaling Pathway to Attenuate Doxorubicin-Induced Cardiomyopathy

Antioxidants, 2023
Doxorubicin (DOX) chemotherapy in cancer patients increases the risk of the occurrence of cardiac dysfunction and even results in congestive heart failure.
Yanyan Ma, Jipeng Ma, Linhe Lu, Xiang Xiong, Yalan Shao, Jun Ren, Jian Yang, Jiankang Liu   +7 more
doaj   +1 more source

Particle Swarm Method for Optimization of ATIG Welding Process to Joint Mild Steel to 316L Stainless Steel

Crystals, 2023
316L stainless steel joined to mild steel is widespread in several applications to reach a requested good association of mechanical properties at a lower cost.
Kamel Touileb, Rachid Djoudjou, Abousoufiane Ouis, Abdeljlil Chihaoui Hedhibi, Sahbi Boubaker, Mohamed M. Z. Ahmed   +5 more
doaj   +1 more source

CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]

, 2013
B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto, A Yoder, AD Bucheit, B Anliker, C Demaison, C Frecha, C Frecha, C Frecha, CA Walshe, Christian J. Buchholz, CJ Buchholz, D Unutmaz, DA Tuveson, DD Sloan, Els Verhoeyen, Evren Alici, François-Loic Cosset, H Li, H Niiro, J Bruenke, J Uchida, JT Golay, K Akashi, K Itoh, L Ginaldi, M Fujimoto, M Kügler, M Peipp, M Serafini, M Zanetti, MD Mühlebach, Michael Schwenkert, MJ Polyak, MS Cragg, NE Harwood, Q Zhou, Q Zhou, Q Zhou, Qi Zhou, R Zufferey, RC Münch, RN Damle, RS Noyce, S Funke, S Kheirallah, S Kneissl, Sabrina Kneissl, T Nakamura, TF Tedder, X Li, Y Reiter, YD Korin   +51 more
core   +3 more sources

Specifities of application of activating fluxes in electrical welding in protective atmosphere [PDF]

FME Transactions, 2020
Without the increase in welding current, activating fluxes for arc welding with a non-consumable electrode (ATIG) and for welding with a consumable electrode (AMIG) allow for the increase in depth of penetration 2-4 times.
Savitskyi Oleksandr M., Savitskyi Mychailo M., Bajić Darko   +2 more
doaj  

Magnetohydrodynamics evolution of three-dimensional magnetic null in NOAA active region 11515 initiated using non-force-free field extrapolation

Frontiers in Astronomy and Space Sciences, 2022
Magnetohydrodynamics simulation of active region NOAA 11515 is performed to examine the initiation of the M5.6 flaring event that starts around 10:43 UT on 2 July 2012.
Sanjay Kumar, Avijeet Prasad, Avijeet Prasad, Ranadeep Sarkar, Ramit Bhattacharyya   +4 more
doaj   +1 more source

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

Cell Reports, 2021
Summary: Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation of ...
Eunice Cho, Hua Jane Lou, Leena Kuruvilla, David A. Calderwood, Benjamin E. Turk   +4 more
doaj   +1 more source

Basal ryanodine receptor activity suppresses autophagic flux [PDF]

Biochemical Pharmacology, 2017
The inositol 1,4,5-trisphosphate receptors (IP3Rs) and intracellular Ca2+ signaling are critically involved in regulating different steps of autophagy, a lysosomal degradation pathway. The ryanodine receptors (RyR), intracellular Ca2+-release channels mainly expressed in excitable cell types including muscle and neurons, have however not yet been ...
Vervliet, T., Pintelon, I., Welkenhuyzen, K., Bootman, M.D., Bannai, H., Mikoshiba, K., Martinet, W., Nadif Kasri, N., Nadif Kasri, N., Parys, J.B., Bultynck, G.   +10 more
openaire   +3 more sources

Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Alcohol-related liver disease (ALD) is characterized by accumulation of hepatic free fatty acids (FFAs) and triglyceride (TG)-enriched lipid droplets and cell death.
Wei Guo, Wei Zhong, Liuyi Hao, Haibo Dong, Xinguo Sun, Ruichao Yue, Tianjiao Li, Zhanxiang Zhou   +7 more
doaj   +1 more source

Cell volume regulation in the proximal tubule of rat kidney proximal tubule cell volume regulation [PDF]

, 2017
We developed a dynamic model of a rat proximal convoluted tubule cell in order to investigate cell volume regulation mechanisms in this nephron segment.
Edwards, Aurelie, Layton, Anita T.
core   +1 more source