Results 101 to 110 of about 6,391,825 (297)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Frontiers in Immunology, 2018 Epstein–Barr Virus (EBV) is a gamma-herpes virus that infects 90% of humans without any symptoms in most cases, but has an oncogenic potential, especially in immunocompromised individuals.
Sylvain Latour +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
CTPS2 regulates CTP synthetase activity by interacting with CTPS1
Life Science AllianceThe human CTP synthetases 1 and 2 associate together and co-localize in large filament–cytoophidium structures. CTPS1 and CTPS2 association results in enzymatic modulation independently of cytoophidia revealing a new regulation mechanism of CTP ...
Norbert Minet +5 more
doaj +1 more source
On Putting the Active Back into Activism
New Formations, 2010 This paper addresses a paradox: how to engage in affirmative politics, which entails the production of social horizons of hope, while at the same time doing critical theory, which means resisting the present. Drawing on the neo-vitalism of Deleuze, with reference to Nietzsche and Spinoza, the article argues in favour of an affirmative ethics: defined ...
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
ChemistryEuropeDiphenylethylenediamine‐derived imidazoline‐amino acid derivatives are designed as nonphosphine chiral nitrogen ligands for metal‐catalyzed exo‐selective [3 + 2] cycloaddition reaction of iminoesters with nitroalkenes.
Yan Yu +4 more
doaj +1 more source
ACE2 ACTIVATION PROMOTES ANTITHROMBOTIC ACTIVITY
The FASEB Journal, 2009 Hyperactivity of the axis ACE/AngII/AT1R of the renin‐angiotensin system is associated with occurrence of acute thrombotic event. Recently a novel concept of a counterrugulatory axis, ACE2/Ang‐(1‐7)/Mas, has emerged. We hypothesized that ACE2 would be protective against thrombosis.
Rodrigo A, Fraga-Silva +10 more
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB
iScienceSummary: Costimulatory signals provided to T cells during antigen encounter have a decisive role in the outcome of immune responses. Here, we used chimeric receptors harboring the extracellular domain of mouse inducible T cell costimulator (mICOS) to ...
Annika De Sousa Linhares +3 more
doaj +1 more source