Results 141 to 150 of about 7,192,603 (344)

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

Molecules and Cells, 2002
F. Martinon, K. Burns, J. Tschopp
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Efficient Graphene Production by Combined Bipolar Electrochemical Intercalation and High-Shear Exfoliation

ACS Omega, 2017
Emil Tveden Bjerglund, Michael Ellevang Pagh Kristensen, Samantha Stambula, Gianluigi A. Botton, Steen Uttrup Pedersen, Kim Daasbjerg   +5 more
doaj   +1 more source

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors [PDF]

, 2019
Rani K. Powers, Rachel Culp‐Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona‐Iragui, Rebecca B. Wilkerson, Darcy Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquı́n M. Espinosa   +20 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Human SREBP1c Expression in Liver Is Directly Regulated by Peroxisome Proliferator-activated Receptor α (PPARα) [PDF]

, 2011
Ana Julia Fernández-Álvarez, María Soledad Álvarez, Raúl González, Carme Cucarella, Jordi Muntané, Marta Casado   +5 more
openalex   +1 more source

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Nature, 1997
R. Medzhitov, P. Preston-Hurlburt, C. Janeway   +2 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19 [PDF]

, 2020
Joe M. McCord, Brooks M. Hybertson, Adela Cota‐Gomez, Kara Geraci, Bifeng Gao   +4 more
openalex   +1 more source

Ovary transplantation: to activate or not to activate [PDF]

Human Reproduction, 2015
Kazuhiro, Kawamura, Yuan, Cheng, Ying-Pu, Sun, Jun, Zhai, Cesar, Diaz-Garcia, Carlos, Simon, Antonio, Pellicer, Aaron J, Hsueh   +7 more
openaire   +2 more sources