Results 21 to 30 of about 7,197,000 (313)

Macrophage activation and polarization: nomenclature and experimental guidelines

Immunity, 2014
Summary Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways.
P. Murray, J. Allen, S. Biswas, E. Fisher, D. Gilroy, S. Goerdt, S. Gordon, J. Hamilton, L. Ivashkiv, T. Lawrence, M. Locati, A. Mantovani, F. Martínez, J. Mege, D. Mosser, G. Natoli, J. Saeij, J. Schultze, K. Shirey, A. Sica, J. Suttles, I. Udalova, J. V. Van Ginderachter, S. Vogel, T. Wynn   +24 more
semanticscholar   +1 more source

Inherited immunodeficiencies associated with proximal and distal defects in T cell receptor signaling and co-signaling

Biomedical Journal, 2022
T lymphocytes are central cells of adaptive immunity. Activation of T lymphocytes by the antigen receptor of T cells (TCR) and co-stimulatory molecules involve specific signaling components and cascades.
Sylvain Latour
doaj   +1 more source

Scalable carbon dioxide electroreduction coupled to carbonylation chemistry

Nature Communications, 2017
Electroreduction of CO2 to CO is a potential valorisation pathway of carbon dioxide for fine chemicals production. Here, the authors show a user-friendly device that couples CO2 electroreduction with carbonylation chemistry for up to gram scale synthesis
Mikkel T. Jensen, Magnus H. Rønne, Anne K. Ravn, René W. Juhl, Dennis U. Nielsen, Xin-Ming Hu, Steen U. Pedersen, Kim Daasbjerg, Troels Skrydstrup   +8 more
doaj   +1 more source

Myosin IIa Promotes Antibody Responses by Regulating B Cell Activation, Acquisition of Antigen, and Proliferation

Cell Reports, 2018
Summary: B cell responses are regulated by antigen acquisition, processing, and presentation to helper T cells. These functions are thought to depend on contractile activity of non-muscle myosin IIa.
Robbert Hoogeboom, Elizabeth M. Natkanski, Carla R. Nowosad, Dessislava Malinova, Rajesh P. Menon, Antonio Casal, Pavel Tolar   +6 more
doaj   +1 more source

The M1 and M2 paradigm of macrophage activation: time for reassessment

F1000Prime Reports, 2014
Macrophages are endowed with a variety of receptors for lineage-determining growth factors, T helper (Th) cell cytokines, and B cell, host, and microbial products.
F. Martínez, S. Gordon
semanticscholar   +1 more source

Development of a novel light-up probe for detection of G-quadruplexes in stress granules

Scientific Reports, 2022
G-quadruplexes (G4s) regulate various biological processes in cells. However, cellular imaging of dynamically forming G4s in biomolecular condensates using small molecules has been poorly investigated. Herein, we present a fluorescent light-up probe with
Keisuke Iida, Natsumi Suzuki, Ayano Sasaki, Shunsuke Ishida, Takayoshi Arai   +4 more
doaj   +1 more source

Exploring the full spectrum of macrophage activation

Nature reviews. Immunology, 2008
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions.
D. Mosser, J. Edwards
semanticscholar   +1 more source

Transcriptional activators and activation mechanisms [PDF]

Protein & Cell, 2007
Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
openaire   +2 more sources

Cooperative redox activation for carbon dioxide conversion

Nature Communications, 2016
While CO2 can be converted to CO for further reactivity, typically this involves the generation of large amounts of waste. Here the authors report the conversion of CO2to CO, with the siloxane by-product being further used in a carbonylative Hiyama ...
Zhong Lian, Dennis U. Nielsen, Anders T. Lindhardt, Kim Daasbjerg, Troels Skrydstrup   +4 more
doaj   +1 more source

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Nature Communications, 2019
The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti, Laurence Bataille, Jean-Marie Carpier, Stéphanie Dogniaux, Mabel San Roman-Jouve, Mathieu Maurin, Michael W. Stuck, Rosa M. Rios, Cosima T. Baldari, Gregory J. Pazour, Claire Hivroz   +10 more
doaj   +1 more source