Results 41 to 50 of about 7,197,000 (313)

New Directions in Transition Metal Catalyzed Carbonylation Chemistry

CHIMIA, 2018
Carbon monoxide (CO) represents an important C1-building block for the construction of some of the most fundamental chemical functionalities carrying a carbon–oxygen double bond.
Dennis U. Nielsen, Karoline T. Neumann, Troels Skrydstrup   +2 more
doaj   +1 more source

A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells

Cells, 2023
CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of the interplay between γ-herpesvirus and host cells in B cell pathogenesis ...
Ursula Rambold, Stefanie Sperling, Zakir Chew, Yan Wang, Beatrix Steer, Krisztina Zeller, Lothar J. Strobl, Ursula Zimber-Strobl, Heiko Adler   +8 more
doaj   +1 more source

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo(*)

Journal of Biological Chemistry, 1995
PD 098059 has been shown previously to inhibit the dephosphorylated form of mitogen-activated protein kinase kinase-1 (MAPKK1) and a mutant MAPKK1(S217E,S221E), which has low levels of constitutive activity (Dudley, D. T., Pang, L., Decker, S.
D. Alessi, A. Cuenda, Philip R. Cohen, D. T. Dudley, A. Saltiel   +4 more
semanticscholar   +1 more source

Active voice, active writing [PDF]

Ubiquity, 2020
Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay. Knowing when to write in the active or passive voice can fundamentally improve your work, but ...
openaire   +1 more source

The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes

Clinical and Developmental Immunology, 2013
Microglia are intrinsic components of the central nervous system (CNS). During pathologies in mammals, inflammatory processes implicate the resident microglia and the infiltration of blood cells including macrophages.
Françoise Le Marrec-Croq, Francesco Drago, Jacopo Vizioli, Pierre-Eric Sautière, Christophe Lefebvre   +4 more
doaj   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

A Highly Sensitive Cell-Based TLR Reporter Platform for the Specific Detection of Bacterial TLR Ligands

Frontiers in Immunology, 2022
Toll-like receptors (TLRs) are primary pattern recognition receptors (PRRs), which recognize conserved microbial components. They play important roles in innate immunity but also in the initiation of adaptive immune responses.
Katharina Radakovics, Claire Battin, Judith Leitner, Sabine Geiselhart, Wolfgang Paster, Johannes Stöckl, Karin Hoffmann-Sommergruber, Peter Steinberger   +7 more
doaj   +1 more source

ACTIVATION FUNCTIONS IN NEURAL NETWORKS

International Journal of Engineering Applied Sciences and Technology, 2020
—Artificial Neural Networks are inspired from the human brain and the network of neurons present in the brain. The information is processed and passed on from one neuron to another through neuro synaptic junctions.
Siddhartha Sharma, Simone Sharma, Anidhya Athaiya   +2 more
semanticscholar   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Journal of Experimental Medicine, 2000
PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features.
G. Freeman, A. Long, Yoshiko Iwai, Karen Bourque, T. Chernova, H. Nishimura, L. Fitz, Nelly Malenkovich, Taku Okazaki, M. Byrne, H. Horton, L. Fouser, L. Carter, V. Ling, M. Bowman, B. Carreno, M. Collins, C. Wood, T. Honjo   +18 more
semanticscholar   +1 more source