Results 171 to 180 of about 4,243,823 (319)

Exploring CRISPR-Mediated Activation of Lineage-Specific Genes for Direct Cellular Reprogramming Using RNPs

openDNA- and Virus-free activation of pluripotency networks offers potential for regenerative medicine and cellular engineering. In this study, a ribonucleoprotein (dRNP)-based CRISPR activation (CRISPRa) system was used to transiently upregulate ...
DORDEVIC, OGNJEN
core  

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation. [PDF]

Glia
Rebeck GW, Shautidze G, Sepulveda J, Healey GS, Narayan PS.   +4 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Is there an alternative to grant-funding for sexual and reproductive health advocacy? A survey of the income base of AmplifyChange grantees

Sexual and Reproductive Health Matters, 2023
Alex le May, Lucie Hazelgrove-Planel
doaj   +1 more source

Task-Evoked Functional Activation and Coupling With CSF Flow Detected in the Human Brain With Ultrashort Echo Time fMRI at 7 T. [PDF]

NMR Biomed
Ponticorvo S, Paasonen E, Filip P, Rothman DL, Valjakka JS, Gröhn O, Michaeli S, Mangia S.   +7 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma. [PDF]

Am J Respir Cell Mol Biol
Reza MI, Tandberg C, Kumar A, Balraj P, Thompson MA, Prakash YS, Pabelick CM, Britt RD, Sathish V.   +8 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity

, 2003
A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the expression and functionality of group III metabotropic glutamate (mGlu) receptors on microglia.
Taylor, D.L., Pocock, J.M., Diemel, L.T.
core  

Children With Idiopathic Toe Walking Display Different Cortical Activation Patterns When Interpreting Tactile Sensation. [PDF]

Dev Psychobiol
Donne JH, Beare R, Powell JA, Fahey MC, Williams CM.   +4 more
europepmc   +1 more source