Results 21 to 30 of about 4,828,539 (266)
Nature Communications, 2022 Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen +4 more
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FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab
Frontiers in Immunology, 2023 IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner +4 more
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Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility
EMBO Molecular Medicine, 2018 Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter +9 more
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Scientific Reports, 2018 A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to ...
Takayoshi Arai +4 more
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Cells, 2021 LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez +5 more
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Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]
, 2010 Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas +39 more
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Interrogating ligand-receptor interactions using highly sensitive cellular biosensors
Nature Communications, 2023 Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk +10 more
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B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments
eLife, 2019 Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto ...
Sophie I Roper +5 more
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, 2022 Hydrogen is a widely used reductive reagent in organic synthesis. The direct reactions between dihydrogen and other organic compounds are very difficult, due to the high stability of hydrogen molecules.
Xinchen, HE +7 more
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Inter-agency co-operation in activation: comparing three vanguard ‘active’ welfare states [PDF]
, 2008 New forms of inter-agency co-operation have gained increasing prominence in the development and delivery of activation strategies. This article compares different models of inter-agency co-operation, drawing on case study research in Denmark, the ...
Lindsay, Colin, McQuaid, Ronald
core +3 more sources