BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
Frontiers in Immunology, 2022 The engagement of the herpesvirus entry mediator (HVEM, TNFRSF14) by the B and T lymphocyte attenuator (BTLA) represents a unique interaction between an activating receptor of the TNFR-superfamily and an inhibitory receptor of the Ig-superfamily.
Claire Battin +5 more
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BTLA Expression and Function Are Impaired on SLE B Cells [PDF]
Frontiers in Immunology, 2021 B- and T-lymphocyte attenuator (BTLA/CD272) is an inhibitory checkpoint molecule expressed on T and B cells. Prior studies reported defective function of BTLA by T cells in patients with systemic lupus erythematosus (SLE), whereas nothing is known about ...
Annika Wiedemann +24 more
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Roles of BTLA in Immunity and Immune Disorders [PDF]
Frontiers in Immunology, 2021 B and T lymphocyte attenuator (BTLA) is one of the most important cosignaling molecules. It belongs to the CD28 superfamily and is similar to programmed cell death-1 (PD-1) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) in terms of its ...
Zhaochen Ning +4 more
doaj +5 more sources
BTLA: An Emerging Immune Checkpoint Target in Cancer Immunotherapy [PDF]
PharmaceuticalsB and T lymphocyte attenuator (BTLA) is a unique co-inhibitory receptor of the CD28 immunoglobulin superfamily that exhibits dual regulatory functions in immune activation and tolerance.
Ming-Cheng Chang +3 more
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Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2
Cells, 2022 B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that mediates the escape of tumor cells from immunosurveillance. Consequently, BTLA and its ligand herpesvirus entry mediator (HVEM) are potentially immunotherapeutic targets. However,
Tian-You Cheng +10 more
doaj +2 more sources
Admission CD4+ T cell BTLA expression and its association with infection risk and respiratory outcomes in sepsis [PDF]
Frontiers in Cellular and Infection MicrobiologyObjectiveT cell co-inhibitory molecule upregulation is linked to sepsis-induced immune suppression, but the relationship between B and T lymphocyte attenuator (BTLA) expression and ICU-acquired infection or organ function recovery in sepsis remains ...
Shuwei Ning +6 more
doaj +2 more sources
Elevated BTLA Expression Correlates with an Immunosuppressive Microenvironment and Defines Dysfunctional Circulating T Cells in Human Glioblastoma [PDF]
Medical SciencesBackground: Successful translation of cancer immunotherapy is underscored by the efficacy of PD-1/PD-L1 and CTLA-4 inhibitors in the treatment of various malignancies.
Sanaa Souat +8 more
doaj +2 more sources
The BTLA/HVEM axis as a key regulator for stratified functional cure in chronic hepatitis B [PDF]
Frontiers in ImmunologyBackgroundFunctional cure rates in chronic hepatitis B (CHB) remain below 10% after long-term nucleos(t)ide analogue (NA) therapy, and PD-1/PD-L1 blockade achieves HBsAg clearance in approximately 30% of selected patients with low baseline HBsAg (≤100 IU/
Yuzhen Zhang +5 more
doaj +2 more sources
BTLA-mediated regulation of neuroimmune responses enhances recovery after intracerebral hemorrhage [PDF]
Journal of NeuroinflammationBackground Modulating harmful neuroimmune responses is a promising therapeutic approach for hemorrhagic stroke, a condition that still lacks effective treatment. The immune checkpoint B and T Lymphocyte Attenuator (BTLA) helps suppress immune activation;
Yuxing Wu +14 more
doaj +2 more sources
miR-155-5p Silencing Does Not Alter BTLA Molecule Expression in CLL T Cells: Implications for Targeted Immunotherapy [PDF]
BiomoleculesGiven that we have demonstrated that miR-155-5p is increased in CLL PBMCs and that its reduction with inhibitory siRNA partially restores the immune checkpoint BTLA protein level in CLL B cells, risk stratification for using anti-miR-155-based ...
Agata Kosmaczewska +11 more
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