The Role of Inhibitory Receptors in Monosodium Urate Crystal-Induced Inflammation [PDF]
Frontiers in Immunology, 2018 Inhibitory receptors are key regulators of immune responses. Aberrant inhibitory receptor function can either lead to an exacerbated or defective immune response.
Maria J. Fernandes, Paul H. Naccache
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Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells [PDF]
Cells, 2023 T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to a persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, LAG3,
Jiahe Lu +14 more
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Editorial: Inhibitory Receptors and Pathways of Lymphocytes [PDF]
Frontiers in Immunology, 2020 Alexandre M. Carmo +3 more
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New Targets for Antiviral Therapy: Inhibitory Receptors and Immune Checkpoints on Myeloid Cells [PDF]
Viruses, 2022 Immune homeostasis is achieved by balancing the activating and inhibitory signal transduction pathways mediated via cell surface receptors. Activation allows the host to mount an immune response to endogenous and exogenous antigens; suppressive ...
Yanni Liu, Paul Nicklin, Yuan He
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Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo [PDF]
eLife, 2021 Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize ...
Taisuke Miyazaki +9 more
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A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets [PDF]
eLifeDespite major successes with inhibitory receptor blockade in cancer, the identification of novel inhibitory receptors as putative drug targets is needed due to lack of durable responses, therapy resistance, and side effects.
Akashdip Singh +10 more
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Recruitment of activation receptors at inhibitory NK cell immune synapses. [PDF]
PLoS ONE, 2008 Natural killer (NK) cell activation receptors accumulate by an actin-dependent process at cytotoxic immune synapses where they provide synergistic signals that trigger NK cell effector functions.
Nicolas Schleinitz +2 more
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Control of Viral Infection by Natural Killer Cell Inhibitory Receptors [PDF]
Cell Reports, 2020 Summary: Major histocompatibility complex class I (MHC-I)-restricted immune responses are largely attributed to cytotoxic T lymphocytes (CTLs). However, natural killer (NK) cells, as predicted by the missing-self hypothesis, have opposing requirements ...
Bijal A. Parikh +7 more
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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. [PDF]
PLoS ONE, 2012 Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking antibodies have already shown clinical benefit for cancer patients.
Lukas Baitsch +13 more
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MHC-I molecules selectively inhibit cell-mediated cytotoxicity triggered by ITAM-coupled activating receptors and 2B4. [PDF]
PLoS ONE, 2014 NK cell effector functions are controlled by a combination of inhibitory receptors, which modulate NK cell activation initiated by stimulatory receptors.
Rubén Corral-San Miguel +4 more
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