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T cell exhaustion in parasitic infections [PDF]
Frontiers in ImmunologyT cell exhaustion is a state of progressive functional impairment that occurs upon persistent antigenic stimulation and is a key mechanism by which chronic parasitic infections evade host immunity.
Ge Gao +4 more
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The impact of T cell exhaustion in hematopoietic stem cell transplantation [PDF]
Stem Cell Research & TherapyT cell exhaustion is a hallmark of failure to control cancer and chronic infection. In hematological malignancies, T cell exhaustion not only relates to disease progression but also impacts the outcome of hematopoietic stem cell transplantation (HSCT ...
Yue Li +6 more
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Multiscale modeling of T cell exhaustion: A mathematical framework integrating continuous dynamics with spatial heterogeneity. [PDF]
PLoS Computational BiologyContinuous antigen exposure drives T cells into a progressive state of dysfunction known as exhaustion, enabling tumors to evade immune surveillance and promoting disease progression.
Chenghang Li +5 more
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Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion
EBioMedicine, 2022 Summary: Chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment with enormous potential, demonstrating impressive antitumor activity in the treatment of hematological malignancies.
Diana Gumber, Leo D. Wang
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PLoS ONE, 2022 T cell exhaustion is a state of T cell dysfunction during chronic infection and cancer. Antibody-targeting immune checkpoint inhibitors to reverse T cell exhaustion is a promising approach for cancer immunotherapy. However, molecular mechanisms of T cell
Lin Zhang, Hafumi Nishi
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CD8+ T Cell Exhaustion in Cancer
Frontiers in Immunology, 2021 A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now ...
Joseph S. Dolina +3 more
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Overcoming T-cell exhaustion in glioblastoma: A narrative review
Glioma, 2022 Immunotherapy is typically ineffective against glioblastoma (GBM) due to inherent and adaptive resistance. Initial immunotherapy results for GBM have been disappointing. In this regard, T-cell exhaustion is a major barrier to successful treatment.
Xuya Wang, Xisen Wang, Jiabo Li
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Exhausted T cells hijacking the cancer-immunity cycle: Assets and liabilities
Frontiers in Immunology, 2023 T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked ...
Anna E. Brunell +4 more
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Mechanisms of CAR T cell exhaustion and current counteraction strategies
Frontiers in Cell and Developmental Biology, 2022 The functional state of chimeric antigen receptor T (CAR T) cells determines their efficacy in vivo. Exhausted CAR T cells exhibit decreased proliferative capacity, impaired anti-tumor activity, and attenuated persistence.
Xiaoying Zhu, Qing Li, Xiaojian Zhu
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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion
OncoImmunology, 2020 Exhaustion cripples T cell effector responses against metastatic cancers and chronic infections alike. There has been considerable interest in understanding the molecular and cellular mechanisms driving T cell exhaustion in human cancers fueled by the ...
Mumtaz Y. Balkhi
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